A new bioactive prenylated dihydroflavanoid from Dolichos tenuicaulis (Baker) Craib

Jin Yong Peng Hai Yan Liu Yan Qi Xu Han You Wei Xu Li Na Xu Qi Wei Xu

引用本文: Jin Yong Peng,  Hai Yan Liu,  Yan Qi,  Xu Han,  You Wei Xu,  Li Na Xu,  Qi Wei Xu. A new bioactive prenylated dihydroflavanoid from Dolichos tenuicaulis (Baker) Craib[J]. Chinese Chemical Letters, 2007, 18(3): 293-296. doi: 10.1016/j.cclet.2007.01.007 shu
Citation:  Jin Yong Peng,  Hai Yan Liu,  Yan Qi,  Xu Han,  You Wei Xu,  Li Na Xu,  Qi Wei Xu. A new bioactive prenylated dihydroflavanoid from Dolichos tenuicaulis (Baker) Craib[J]. Chinese Chemical Letters, 2007, 18(3): 293-296. doi: 10.1016/j.cclet.2007.01.007 shu

A new bioactive prenylated dihydroflavanoid from Dolichos tenuicaulis (Baker) Craib

  • 基金项目:

    The authors thank Dr. Genjin Yang (Second Military Medical University,Shanghai,China) for his performing 1D and 2D NMR experiments.

摘要: A new prenylated dihydroflavonoid was obtained from the root of Dolichos tenuicaulis (Baker) Craib. The structure was elucidated as (2S)-5,2',6'-trihydroxy-3''', 8-di (γ, γ-dimethyl-allyl)-2''', 2'''-dimethylpyrano-[5''',6''':6,7]-2''''',4'''''-cyclohexadiene-1'''''-one-[2''''',3''''':3',4']-flavanone, named dolichnin A, by spectroscopic methods including UV, IR, HR-EI-MS, 1D NMR and 2D NMR techniques, and subsequently, the anticancer activity of this compound to inhibit human cancer cells' growth including A549, BEL-7402, Hep-3B, SMMC7721, HT-29, MCF-7, SGC-7902, K562, A498 and PC3 cell lines by MTT method was evaluated in vitro.

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  • 收稿日期:  2006-10-10
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