Citation:
LU Guang-Ying, FANG Jun. Synthesis, Antibacterial Activities and Theoretical Studies of Benzopyranocoumarin Derivatives[J]. Chinese Journal of Structural Chemistry,
2016, 34(10): 1606-1611.
doi:
10.14102/j.cnki.0254-5861.2011-0483
Synthesis, Antibacterial Activities and Theoretical Studies of Benzopyranocoumarin Derivatives
摘要:
Three benzopyranocoumarins (OBH, OMH and ODH) were synthesized and characterized via IR, 1H NMR and HRMS. The HB energy in OBH, OMH and ODH was performed with the density functional theory (DFT) [B3LYP/6-31G*] method. The in vitro antibacterial activity of OBH, OMH and ODH against drug-sensitive S. aureus (S. aureus ATCC 29213) strain, MRSA strain (MRSA XJ 75302), drug-sensitive S. epidermidis strain (S. epidermidis ATCC 14990) and methicillin-resistant S. epidermidis strain (MRSE XJ 75284) was evaluated by observing the minimum inhibitory concentration. The results showed that among the three compounds, ODH exhibited the most potent antibacterial activity.
English
Synthesis, Antibacterial Activities and Theoretical Studies of Benzopyranocoumarin Derivatives
Abstract:
Three benzopyranocoumarins (OBH, OMH and ODH) were synthesized and characterized via IR, 1H NMR and HRMS. The HB energy in OBH, OMH and ODH was performed with the density functional theory (DFT) [B3LYP/6-31G*] method. The in vitro antibacterial activity of OBH, OMH and ODH against drug-sensitive S. aureus (S. aureus ATCC 29213) strain, MRSA strain (MRSA XJ 75302), drug-sensitive S. epidermidis strain (S. epidermidis ATCC 14990) and methicillin-resistant S. epidermidis strain (MRSE XJ 75284) was evaluated by observing the minimum inhibitory concentration. The results showed that among the three compounds, ODH exhibited the most potent antibacterial activity.
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