A new and efficient method for the synthesis of isoquinoline-3-carboxylate

Xiang Wei Liao Bao He Guan Zhan Zhu Liu

引用本文: Xiang Wei Liao,  Bao He Guan,  Zhan Zhu Liu. A new and efficient method for the synthesis of isoquinoline-3-carboxylate[J]. Chinese Chemical Letters, 2008, 19(3): 253-255. doi: 10.1016/j.cclet.2007.12.025 shu
Citation:  Xiang Wei Liao,  Bao He Guan,  Zhan Zhu Liu. A new and efficient method for the synthesis of isoquinoline-3-carboxylate[J]. Chinese Chemical Letters, 2008, 19(3): 253-255. doi: 10.1016/j.cclet.2007.12.025 shu

A new and efficient method for the synthesis of isoquinoline-3-carboxylate

  • 基金项目:

    We thank the National Natural Sciences Foundation of China (No. 30672518) and Specialized Research Fund for the Doctoral Program of Higher Education (No. 20060023025) for financial support.

摘要: An isoquinoline-3-carboxylate compound 3 was obtained with a moderate yield of 40% when N-acetyl-(3'-hydroxy-4'-methoxy-5'-methyl) phenylalanine methyl ester 1 was refluxed in HMTA/TFA. However, the anticipated product N-acetyl-(3'-hydroxy-4'-methoxy-5'-methyl-6'-formyl) phenylalanine methyl ester 2 could not be found. The possible mechanism was discussed in this article.

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  • 收稿日期:  2007-11-05
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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