引用本文:
Hai Bo Sun, Guo Jun Zheng, Ya Ping Wang, Xiang Jing Wang, Wen Sheng Xiang. Novel synthesis of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde: A key intermediate of Losartan[J]. Chinese Chemical Letters,
2009, 20(3): 269-270.
doi:
10.1016/j.cclet.2008.11.031
Citation: Hai Bo Sun, Guo Jun Zheng, Ya Ping Wang, Xiang Jing Wang, Wen Sheng Xiang. Novel synthesis of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde: A key intermediate of Losartan[J]. Chinese Chemical Letters, 2009, 20(3): 269-270. doi: 10.1016/j.cclet.2008.11.031
Citation: Hai Bo Sun, Guo Jun Zheng, Ya Ping Wang, Xiang Jing Wang, Wen Sheng Xiang. Novel synthesis of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde: A key intermediate of Losartan[J]. Chinese Chemical Letters, 2009, 20(3): 269-270. doi: 10.1016/j.cclet.2008.11.031
Novel synthesis of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde: A key intermediate of Losartan
摘要:
Anovelmethod for synthesis of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde 2, a key intermediate of Losartan was reported. The compound 2 was synthesized fromstarting material dimethyl malonate 6 and n-valeronitrile 8 by six steps with an overall yield of 40%.The key step including the reaction of compound 5 with POCl3/DMF followed by hydrolysis to give compound 2 with the yield of 68%.
English
Novel synthesis of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde: A key intermediate of Losartan
Abstract:
Anovelmethod for synthesis of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde 2, a key intermediate of Losartan was reported. The compound 2 was synthesized fromstarting material dimethyl malonate 6 and n-valeronitrile 8 by six steps with an overall yield of 40%.The key step including the reaction of compound 5 with POCl3/DMF followed by hydrolysis to give compound 2 with the yield of 68%.
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