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化学-酶催化制备天然丹参素

杨玲英 ,  曾庆友 ,  杨道茂

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引用本文: 杨玲英, 曾庆友, 杨道茂. 化学-酶催化制备天然丹参素[J]. 应用化学, 2016, 33(9): 1073-1078. doi: 10.11944/j.issn.1000-0518.2016.09.150444 shu
Citation:  YANG Lingying, ZENG Qingyou, YANG Daomao. Chemoenzymatic Synthesis of Danshensu[J]. Chinese Journal of Applied Chemistry, 2016, 33(9): 1073-1078. doi: 10.11944/j.issn.1000-0518.2016.09.150444 shu

化学-酶催化制备天然丹参素

  • 1.

    华侨大学化工学院 福建 厦门 361021

    • 通讯作者: 曾庆友,副教授;Tel/Fax:0592-6162300;E-mail:tonyzeng@hqu.edu.cn;研究方向:药物合成及药物输送系统
  • 基金项目:

    中央高校基本科研业务费专项资金资助项目（JB-ZR1153） 

摘要: 丹参素是中药丹参的水溶性化学成分之一，具有很多潜在的药理活性。以3，4-二羟基苯甲醛和乙酰甘氨酸为原料，经Erlenmeyer反应并开环得到α-乙酰氨基-β-（3，4-二乙酰氧基苯基）丙烯酸、盐酸水解制得β-（3，4-二羟基苯基）丙酮酸，再经乳酸片球菌1.2696静息细胞生物酶催化还原合成了天然右旋丹参素，总收率69.4%，丹参素对映体过量值97.5%。

English

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  • 收稿日期:  2015-12-14
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