引用本文:
贺怀贞, 李剑利, 武祥龙, 王陆瑶, 史真. α-萘基环己基甲基酮仿生合成新方法[J]. 应用化学,
2006, 23(6): 685-687.
Citation: HE Huai-Zhen, LI Jian-Li, WU Xiang-Long, Wang Lu-Yao, SHI Zhen. Biomimetic Synthesis of 1-Naphthyl Cyclohexyl Ketone[J]. Chinese Journal of Applied Chemistry, 2006, 23(6): 685-687.
Citation: HE Huai-Zhen, LI Jian-Li, WU Xiang-Long, Wang Lu-Yao, SHI Zhen. Biomimetic Synthesis of 1-Naphthyl Cyclohexyl Ketone[J]. Chinese Journal of Applied Chemistry, 2006, 23(6): 685-687.
α-萘基环己基甲基酮仿生合成新方法
摘要:
模拟四氢叶酸辅酶转移一碳单元的反应,以苯并咪唑甲基碘盐作为甲酸氧化态的四氢叶酸辅酶模型,以Grignard试剂作为一碳单元的接受体,通过加成-水解反应为α-萘基环己基甲基酮提供了一种仿生合成新方法。产物α-萘基环己基甲基酮采用IR、MS、1H NMR测试技术进行了表征,通过反应机理及反应条件对收率的影响进行了讨论。
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关键词:
- 四氢叶酸辅酶
- / 苯并咪唑甲基碘盐
- / Grignard试剂
- / α-萘基环己基甲基酮
- / 仿生合成
English
Biomimetic Synthesis of 1-Naphthyl Cyclohexyl Ketone
Abstract:
Based on the one-carbon unit transfer reaction of tetrahydrofolate coenzymes,α-naphthyl cyclo-hexyl ketone was synthesized successfully with benzoimidazolium salt as the tetrahydrofolate coenzyme model at formic acid oxidation level and Grignard reagent as a nucleophile to which one carbon unit was transferred via addition-hydrolysis reaction.This provides a new convenient biomimetic synthesis method to the title compound.The α-naphthyl cyclohexyl ketone was characterized by means of IR spectra,MS and 1H NMR.The reaction mechanism and the effects of reaction conditions on the yield were investigated.
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