引用本文:
魏佳, 田嫚嫚, 石德清. N1-(四氢呋喃-2-基)-N3-烷基巯基烷基-5-氟尿嘧啶及其氧化产物的合成[J]. 应用化学,
2006, 23(6): 655-658.
Citation: WEI Jia, TIAN Man-Man, SHI De-Qing. Synthesis of N1-(2-furanidyl)-N3-Alkylthioalkyl-5-Fluorouracil and its Oxidized Products[J]. Chinese Journal of Applied Chemistry, 2006, 23(6): 655-658.
Citation: WEI Jia, TIAN Man-Man, SHI De-Qing. Synthesis of N1-(2-furanidyl)-N3-Alkylthioalkyl-5-Fluorouracil and its Oxidized Products[J]. Chinese Journal of Applied Chemistry, 2006, 23(6): 655-658.
N1-(四氢呋喃-2-基)-N3-烷基巯基烷基-5-氟尿嘧啶及其氧化产物的合成
English
Synthesis of N1-(2-furanidyl)-N3-Alkylthioalkyl-5-Fluorouracil and its Oxidized Products
Abstract:
Nine N1-furanidin-2'-yl-N3-alkylsulphonylalkyl-5-fluorouracils were synthesized via the oxidations of N1-furanidin-2'-yl-N3-alkylthioalkyl-5-fluorouracils 2.The intermediates 2 were prepared by the reactions of N1-furanidin-2'-yl-N3-bromoalkyl-5-fluorouracil 1 with sodium alkylsulfide.The structures of the products were confirmed by means of 1H NMR,IR,MS and elemental analysis.The inhibitory activities of compounds 3 to A549,HCT-8 and Bel-7402 cancer cells were tested in vitro.
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Key words:
- fluorouracil
- / sulfone
- / antitumor drug
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