引用本文:
鲍俊杰, 许戈文, 刘都宝, 纪学顺. 水性聚氨酯-聚丙烯酰胺IPN水凝胶的合成及性能[J]. 应用化学,
2008, 25(5): 587-591.
Citation: BAO Jun-Jie, XU Ge-Wen, LIU Du-Bao, JI Xue-Shun. Synthesis of Waterborne Polyurethane-polyacrylamide IPN Biomedical Hydrogels[J]. Chinese Journal of Applied Chemistry, 2008, 25(5): 587-591.
Citation: BAO Jun-Jie, XU Ge-Wen, LIU Du-Bao, JI Xue-Shun. Synthesis of Waterborne Polyurethane-polyacrylamide IPN Biomedical Hydrogels[J]. Chinese Journal of Applied Chemistry, 2008, 25(5): 587-591.
水性聚氨酯-聚丙烯酰胺IPN水凝胶的合成及性能
摘要:
由异佛尔酮二异氰酸酯(IPDI)、聚醚(N-220)、二羟甲基丙酸(DMPA)、三羟甲基丙烷(TMP)等合成了交联型水性聚氨酯,在此乳液中加入丙烯酰胺、交联剂、引发剂进行自由基聚合,制备了具有IPN结构的聚氨酯-聚丙烯酰胺(PU-PAAm)水凝胶,并采用IR、DSC、TEM等测试技术进行了分析和观察。结果表明,经分步IPN聚合得到了PU-PAAm水凝胶。PU-PAAm干胶具有胞状形态结构,并具有较好的相容性。IPN结构的PU-PAAm水凝胶具有协同效应,当m(PU):m(PAAm)=50:60时,溶胀比最大达到11.16。对水凝胶采用TNO、ZX-10和壳聚糖3种抗菌药物载药,测试结果表明,前2种载药水凝胶具有较好的抗菌性能,显示出较好的载药性,但此水凝胶对壳聚糖载药性能不佳。
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关键词:
- 水性聚氨酯(WPU)
- / 聚丙烯酰胺(PAAm)
- / 互穿网络(IPN)
- / 水凝胶
- / 抗菌
English
Synthesis of Waterborne Polyurethane-polyacrylamide IPN Biomedical Hydrogels
Abstract:
Interpenetrating polymer network (IPN) hydrogels composed of waterborne polyurethane (WPU) and polyacrylamide (PAAm) were synthesized.Crosslinked WPU was synthesised from IPDI,N220,DMPA and TMP.Then AAm,DEGDA as crosslinking agent and potassium persulfate (KPS) as initiator were added to form the IPN waterborne polyurethane-polyacrylamide (PU-PAAm) hydrogels.IR,DSC,TEM and the swelling ratio of the hydrogels indicated that the PU-PAAm had cell-like structure,and the components exhibited good compatibility.PU-PAAm IPN hydrogels showed synergistic effect,with the synthesized hydrogel with m(PU):m(PAAm)=50:60 showing the highest SR of 11.16.TNO,ZX-10 and chitosan were respectively loaded in the hydrogels,and the hydrogels carrying TNO and ZX-10 showed good antibacterial activity.
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