Fe<sub>3</sub>O<sub>4</sub>/壳聚糖季铵盐磁共振造影剂的制备及肝造影性能

引用本文: 宋晓丽, 骆夏丹, 李凌, 朱爱萍. Fe₃O₄/壳聚糖季铵盐磁共振造影剂的制备及肝造影性能[J]. 无机化学学报, 2015, 31(10): 1987-1992. doi: 10.11862/CJIC.2015.230 shu

Citation: SONG Xiao-Li, LUO Xia-Dan, LI Ling, ZHU Ai-Ping. Preparation and Liver MRI of Fe₃O₄/N-(2-Hydroxyl)propyl-3-trimethyl Ammonium Chitosan Contrast Agent[J]. Chinese Journal of Inorganic Chemistry, 2015, 31(10): 1987-1992. doi: 10.11862/CJIC.2015.230 shu

Fe₃O₄/壳聚糖季铵盐磁共振造影剂的制备及肝造影性能

宋晓丽 ^{1,
,} ,
骆夏丹 ^2, ,
李凌 ^1, ,
朱爱萍 ^{1,
,}

1.
1 扬州大学化学化工学院, 扬州 225002;
2.
2 金华市环境科学研究院, 金华 321000

通讯作者: 宋晓丽,E-mail:xlsong@yzu.edu.cn;朱爱萍,E-mail:apzhu@yzu.edu.cn; 宋晓丽,E-mail:xlsong@yzu.edu.cn;朱爱萍,E-mail:apzhu@yzu.edu.cn

基金项目:
国家自然科学基金(No.21201149) (No.21201149)

江苏省自然科学基金(BK2012259)资助项目。 (BK2012259)

摘要: 采用季铵盐化壳聚糖(HTCC)对Fe₃O₄进行表面改性,成功制备在模拟生理环境中悬浮稳定的超顺磁性Fe₃O₄/HTCC复合纳米粒。通过动态光散射、透射电镜、振动样品磁强计、磁共振等手段对材料的性能进行表征,并考察了其细胞相容性及磁共振造影性能。结果表明:该方法所制备的超顺磁性复合纳米粒粒径均一,模拟生理环境中具有良好的分散稳定性;体外实验表明该磁性纳米粒具有良好的细胞相容性;大鼠体内肝脏磁共振造影实验表明Fe₃O₄/HTCC纳米粒注入后,大鼠肝实质信号强度明显下降,因此Fe₃O₄/HTCC纳米粒有望作为潜在的阴性造影剂应用于肝磁共振造影检测。

关键词:

季铵盐化壳聚糖;超顺磁性四氧化三铁;分散稳定性;磁共振造影

English

Preparation and Liver MRI of Fe₃O₄/N-(2-Hydroxyl)propyl-3-trimethyl Ammonium Chitosan Contrast Agent

SONG Xiao-Li ^{1,
,} ,
LUO Xia-Dan ^2, ,
LI Ling ^1, ,
ZHU Ai-Ping ^{1,
,}

1.
1 College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China;
2.
2 Jinhua Research Academy of Environmental Sciences, Jinhua, Zhejiang 321000, China

Corresponding author: 宋晓丽,E-mail:xlsong@yzu.edu.cn;朱爱萍,E-mail:apzhu@yzu.edu.cn; 宋晓丽,E-mail:xlsong@yzu.edu.cn;朱爱萍,E-mail:apzhu@yzu.edu.cn

Received Date: 11 March 2015
Fund Project:
国家自然科学基金(No.21201149)

江苏省自然科学基金(BK2012259)资助项目。

Abstract: Supermagnetic Fe₃O₄/N-(2-hydroxyl)propyl-3-trimethyl ammonium chitosan nanoparticles were synthesized by combining Fe₃O₄ and CS chemically modified with glycidyl trimethyl ammonium chloride. Properties of the obtained nanoparticles were investigated by transmission electron microscopy, dynamic light scattering, magnetic resonance imaging and vibration sample magnetometer. The cytocompatibility of the nanoparticles were assessed. Then the in vivo MRI of the nanoparticles were confirmed. The results demonstrate that the nanoparticles are uniform and stable in simulated physiological environment. Also the nanoparticles show good cyto-compatibility. The in vivo results show that the parenchyma signal intensity of rats liver is significantly decreased after injection of the nanoparticles. Thus it indicates that the nanoparticles have potential application in liver MRI as a negative contrast.

Key words:

N-(2-hydroxyl)propyl-3-trimethyl ammonium chitosan;supermagnetic Fe₃O₄;suspension stablility;magnetic resonance imaging

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Fe₃O₄/壳聚糖季铵盐磁共振造影剂的制备及肝造影性能

通讯作者: 宋晓丽,E-mail:xlsong@yzu.edu.cn;朱爱萍,E-mail:apzhu@yzu.edu.cn; 宋晓丽,E-mail:xlsong@yzu.edu.cn;朱爱萍,E-mail:apzhu@yzu.edu.cn

English

Preparation and Liver MRI of Fe₃O₄/N-(2-Hydroxyl)propyl-3-trimethyl Ammonium Chitosan Contrast Agent

Corresponding author: 宋晓丽,E-mail:xlsong@yzu.edu.cn;朱爱萍,E-mail:apzhu@yzu.edu.cn; 宋晓丽,E-mail:xlsong@yzu.edu.cn;朱爱萍,E-mail:apzhu@yzu.edu.cn

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Fe3O4/壳聚糖季铵盐磁共振造影剂的制备及肝造影性能

通讯作者: 宋晓丽,E-mail:xlsong@yzu.edu.cn;朱爱萍,E-mail:apzhu@yzu.edu.cn; 宋晓丽,E-mail:xlsong@yzu.edu.cn;朱爱萍,E-mail:apzhu@yzu.edu.cn

English

Preparation and Liver MRI of Fe3O4/N-(2-Hydroxyl)propyl-3-trimethyl Ammonium Chitosan Contrast Agent

Corresponding author: 宋晓丽,E-mail:xlsong@yzu.edu.cn;朱爱萍,E-mail:apzhu@yzu.edu.cn; 宋晓丽,E-mail:xlsong@yzu.edu.cn;朱爱萍,E-mail:apzhu@yzu.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

Fe₃O₄/壳聚糖季铵盐磁共振造影剂的制备及肝造影性能

Preparation and Liver MRI of Fe₃O₄/N-(2-Hydroxyl)propyl-3-trimethyl Ammonium Chitosan Contrast Agent

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs