注册 English

β-环糊精修饰的荧光金纳米簇的合成及其在细胞成像上的应用

孙敬华 ,  张卫 ,  谭彩萍 ,  计亮年 ,  毛宗万

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引用本文: 孙敬华, 张卫, 谭彩萍, 计亮年, 毛宗万. β-环糊精修饰的荧光金纳米簇的合成及其在细胞成像上的应用[J]. 无机化学学报, 2015, 31(9): 1913-1918. doi: 10.11862/CJIC.2015.239 shu
Citation:  SUN Jing-Hua, ZHANG Wei, TAN Cai-Ping, JI Liang-Nian, MAO Zong-Wan. Synthesis of β-Cyclodextrin Functionalized Fluorescent Gold Nanoclusters for Cellular Imaging[J]. Chinese Journal of Inorganic Chemistry, 2015, 31(9): 1913-1918. doi: 10.11862/CJIC.2015.239 shu

β-环糊精修饰的荧光金纳米簇的合成及其在细胞成像上的应用

  • 1.

    生物无机与合成化学教育部重点实验室;中山大学化学与化学工程学院, 广州 510275

    • 通讯作者: 毛宗万,E-mail:cesmzw@mail.sysu.edu.cn
  • 基金项目:

    国家自然科学基金(No.21231007) (No.21231007)

    国家重点基础研究发展计划(973计划)(No.2014CB845604)资助项目。 (973计划)(No.2014CB845604)

摘要: 通过一锅法水相合成出一种β-环糊精修饰的荧光金簇。该新型金簇具有红色荧光发射、长时间的分散稳定性和荧光稳定性。透射电镜观察其平均粒径为(1.40±0.32)nm。激光共聚焦显示金簇分散在细胞质中,荧光随金簇浓度增加而增强。细胞毒性实验证实该金簇具有良好的生物相容性。表面修饰的β-环糊精,也为金簇载药或者靶向功能化提供了更多可能性,从而进一步拓宽其在生物医学方面的应用。

English

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  • 收稿日期:  2015-07-09
  • 网络出版日期:  2015-07-27
通讯作者: 陈斌, bchen63@163.com
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