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靶向抑制拓扑异构酶和端粒酶的钌配合物研究进展

陈相 ,  巢晖 ,  计亮年

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引用本文: 陈相, 巢晖, 计亮年. 靶向抑制拓扑异构酶和端粒酶的钌配合物研究进展[J]. 无机化学学报, 2015, 31(9): 1667-1677. doi: 10.11862/CJIC.2015.241 shu
Citation:  CHEN Xiang, CHAO Hui, JI Liang-Nian. New Trends of Ruthenium Complexes as Inhibitors Targeting Topoisomerase and Telomerase[J]. Chinese Journal of Inorganic Chemistry, 2015, 31(9): 1667-1677. doi: 10.11862/CJIC.2015.241 shu

靶向抑制拓扑异构酶和端粒酶的钌配合物研究进展

  • 1.

    中山大学化学与化学工程学院生物无机与合成化学教育部重点实验室, 广州 510275

    • 通讯作者: 巢晖,E-mail:ceschh@mail.sysu.edu.cn;计亮年,E-mail:cesjln@mail.sysu.edu.cn; 巢晖,E-mail:ceschh@mail.sysu.edu.cn;计亮年,E-mail:cesjln@mail.sysu.edu.cn
  • 基金项目:

    973项目(No.2015CB85630) (No.2015CB85630)

    国家自然科学基金(No.21172273,21171177,21471164) (No.21172273,21171177,21471164)

    教育部高校博士点基金博导类课题(No.20110171110013)资助项目。 (No.20110171110013)

摘要: 金属配合物抗肿瘤研究,尤其是铂类药物,已取得了相对令人瞩目的成功,但同时也面临着包括耐药性和毒副作用等诸多问题。近年来钌配合物作为新的抗癌药物引起了人们的注意。在非铂系药物中,金属钌配合物是最有前途的抗癌药物之一,国际上普遍认为钌和钌的配合物属于低毒性,容易吸收并在体内很快排泄。本文将着重介绍钌配合物与DNA结合后进一步引发的细胞内核酶活性抑制研究,从新的角度来诠释钌配合物的抗肿瘤研究最新进展。

English

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  • 收稿日期:  2015-05-20
  • 网络出版日期:  2015-07-15
通讯作者: 陈斌, bchen63@163.com
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