A facile approach to tricyclo[6.4.0.04,9]-dodecane framework

Dong Wang William E. Crowe

Citation:  Dong Wang, William E. Crowe. A facile approach to tricyclo[6.4.0.04,9]-dodecane framework[J]. Chinese Chemical Letters, 2015, 26(2): 238-242. doi: 10.1016/j.cclet.2014.11.003 shu

A facile approach to tricyclo[6.4.0.04,9]-dodecane framework

    通讯作者: Dong Wang,
  • 基金项目:

    We thank Frank Fronczek (LSU) for assistance with X-ray crystallography. Financial support from TianJin Municipal Science  (LSU)

    Technology Commission (No. 11ZCKFSY06200) is greatly acknowledged. (No. 11ZCKFSY06200)

摘要: The unusual tricyclo[6.4.0.04,9]dodecane framework was constructed in eight linear steps in 13% overall yield. An innovative strategy accessing the framework from bicyclo[3.3.1]nonanes was employed. The key steps involve a Robinson annulation, a base induced decarboxylation and epimerization in a single step, and an intramolecular alkylation.

English

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  • 发布日期:  2014-11-10
  • 收稿日期:  2014-08-17
  • 网络出版日期:  2014-10-21
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