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Divergent pathways of β,γ-unsaturated α-diazocarbonyl compounds catalyzed by dirhodium and Lewis acids catalysts separately or in combination

Xin-Fang Xu ,  Michael P. Doyle

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Citation:  Xin-Fang Xu, Michael P. Doyle. Divergent pathways of β,γ-unsaturated α-diazocarbonyl compounds catalyzed by dirhodium and Lewis acids catalysts separately or in combination[J]. Chinese Chemical Letters, 2015, 26(2): 227-232. doi: 10.1016/j.cclet.2014.12.014 shu

Divergent pathways of β,γ-unsaturated α-diazocarbonyl compounds catalyzed by dirhodium and Lewis acids catalysts separately or in combination

    • 通讯作者: Xin-Fang Xu,
  • 基金项目:

    MPD is grateful to the National Institutes of Health (No. GM 46503)  (No. GM 46503)

    the National Science Foundation (No. CHE-1212446). XFX is thankful to the starting funding from Soochow University  (No. CHE-1212446)

摘要: β,γ-Unsaturated α-diazocarbonyl compounds possess two reactive sites for electrophilic addition -one at the diazo carbon and the other at the vinylogous g-position. Controlled by catalyst, divergent transformations are achieved starting from the same starting materials, either by Lewis acid-catalyzed addition or by dirhodium-catalyzed metal carbene reactions. In select cases two catalysts working in combination or in sequence provide a relay for cascade transformations. In this review, we summarize advances in catalyst-dependent divergent transformations of β,γ-unsaturated α-diazocarbonyl compounds and highlight the potential of this exciting research area and the many challenges that remain.

English

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  • 发布日期:  2014-12-31
  • 收稿日期:  2014-11-13
  • 网络出版日期:  2014-12-11
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