Determination of benzoic acid in milk by solid-phase extraction and ion chromatography with conductivity detection

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Determination of benzoic acid in milk by solid-phase extraction and ion chromatography with conductivity detection

Zong-Hua Wang , Jian-Fei Xia , Fu-Yong Zhao , Qiang Han , Xin-Mei Guo , Hui Wang , Ming-Yu Ding

Citation: Zong-Hua Wang, Jian-Fei Xia, Fu-Yong Zhao, Qiang Han, Xin-Mei Guo, Hui Wang, Ming-Yu Ding. Determination of benzoic acid in milk by solid-phase extraction and ion chromatography with conductivity detection[J]. Chinese Chemical Letters, 2013, 24(3): 243-245. shu

shu

Determination of benzoic acid in milk by solid-phase extraction and ion chromatography with conductivity detection

通讯作者: Zong-Hua Wang,

摘要: A simple, fast, precise and eco-friendly method, based on ion chromatography (IC) with a suppressed conductivity detector, was proposed for the determination of benzoic acid (BA) inmilk in this paper. The chromatographic separation was accomplished by using an anion exchange column eluted with 3.2 μmol/L aqueous Na₂CO₃ and 1.0 mmol/L aqueous NaHCO₃ at a flow-rate of 0.7 mL/min. Themethod validation experiment provided excellent results with respect to linearity (correlation coefficient up to 0.9997), limit of detection (0.1 μg/L), recovery values (ranging from 88.0% to 93.0%) and relative standard deviation (RSD) (below 2.2%, n = 7).

关键词:

English

Determination of benzoic acid in milk by solid-phase extraction and ion chromatography with conductivity detection

1.
a Laboratory of Fiber Materials and Modern Textile, The Growing Base for State Key Laboratory, College of Chemical and Environment Engineering, Qingdao University, Qingdao 266071, China;
b Metrohm China Ltd.
b Metrohm China Ltd., Beijing 100005, China;
3.
c Beijing Key Laboratory for Microanalytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing 100084, China

Corresponding author: Zong-Hua Wang,

Received Date: 08 November 2012
Available Online: 06 March 2013

Abstract: A simple, fast, precise and eco-friendly method, based on ion chromatography (IC) with a suppressed conductivity detector, was proposed for the determination of benzoic acid (BA) inmilk in this paper. The chromatographic separation was accomplished by using an anion exchange column eluted with 3.2 μmol/L aqueous Na₂CO₃ and 1.0 mmol/L aqueous NaHCO₃ at a flow-rate of 0.7 mL/min. Themethod validation experiment provided excellent results with respect to linearity (correlation coefficient up to 0.9997), limit of detection (0.1 μg/L), recovery values (ranging from 88.0% to 93.0%) and relative standard deviation (RSD) (below 2.2%, n = 7).

Key words:

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