基于核磁和质谱分析技术的代谢组学在癌症诊断中的应用

顾海巍 亓云鹏 许柠 丁健桦 安艳波 陈焕文

引用本文: 顾海巍, 亓云鹏, 许柠, 丁健桦, 安艳波, 陈焕文. 基于核磁和质谱分析技术的代谢组学在癌症诊断中的应用[J]. 分析化学, 2012, 40(12): 1933-1937. doi: 10.3724/SP.J.1096.2012.10542 shu
Citation:  GU Hai-Wei, QI Yun-Peng, XU Ning, DING Jian-Hua, AN Yan-Bo, CHEN Huan-Wen. Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry-based Metabolomics for Cancer Diagnosis[J]. Chinese Journal of Analytical Chemistry, 2012, 40(12): 1933-1937. doi: 10.3724/SP.J.1096.2012.10542 shu

基于核磁和质谱分析技术的代谢组学在癌症诊断中的应用

    通讯作者: 陈焕文
  • 基金项目:

    本文系国家自然科学基金(Nos.21005015,30901981) (Nos.21005015,30901981)

    国家重大仪器专项(No.2011YQ170067) (No.2011YQ170067)

    普度大学研究基金(美国)项目资助 (美国)

摘要: 本文对近年来用于癌症诊断的新方法——代谢组学及其在该领域内的应用进行了简要介绍。代谢组学通过定性与定量测量生物样本(血液、尿液、组织等)中数以千计的小分子代谢物,可灵敏地反映代谢组中与病理状态有关的细微变化,从而可为癌症的早期诊断及更好地理解癌变过程提供一种新颖的思路。本文还讨论了代谢组学与系统生物学中其它一些组学在癌症检测上的关联,介绍了一些用代谢组学进行不同癌症的诊断、治疗监测以及药物开发的前期研究工作,并探讨了用于临床癌症诊断的代谢组学方法所面临的机遇、挑战与未来发展方向。

English

  • 
    1. [1]

      1 Siegel R, Naishadham D, Jemal A. CA. Cancer J. Clin., 2012, 62(1): 10-291 Siegel R, Naishadham D, Jemal A. CA. Cancer J. Clin., 2012, 62(1): 10-29

    2. [2]

      2 Ministry of Health, the People's Republic of China. Report on the Third National Sampling Survey of Causes of Death. Beijing: The People's Health Press, 20082 Ministry of Health, the People's Republic of China. Report on the Third National Sampling Survey of Causes of Death. Beijing: The People's Health Press, 2008

    3. [3]

      3 Belkowski S M, Polkovitch D, D'Andrea M R. Curr. Top. Med. Chem., 2005, 5(11): 1047-10513 Belkowski S M, Polkovitch D, D'Andrea M R. Curr. Top. Med. Chem., 2005, 5(11): 1047-1051

    4. [4]

      4 Lu W L, Jansen L, Post W J, Bonnema J, Velde J C V d, Bock G H D. Breast Cancer Res. Treat., 2009, 114(3): 403-4124 Lu W L, Jansen L, Post W J, Bonnema J, Velde J C V d, Bock G H D. Breast Cancer Res. Treat., 2009, 114(3): 403-412

    5. [5]

      5 Nicholson J K, Lindon J C, Holmes E. Xenobiotica, 1999, 29(11): 1181-11895 Nicholson J K, Lindon J C, Holmes E. Xenobiotica, 1999, 29(11): 1181-1189

    6. [6]

      6 Gowda G A N, Zhang S C, Gu H W, Asiago V, Shanaiah N, Raftery D. Expert Rev. Mol. Diagn., 2008, 8(5): 617-6336 Gowda G A N, Zhang S C, Gu H W, Asiago V, Shanaiah N, Raftery D. Expert Rev. Mol. Diagn., 2008, 8(5): 617-633

    7. [7]

      7 Fiehn O. Plant Mol. Biol., 2002, 48(1-2): 155-1717 Fiehn O. Plant Mol. Biol., 2002, 48(1-2): 155-171

    8. [8]

      8 Wu Z M, Huang Z Q, Lehmann R, Zhao C X, Xu G W. Chromatographia, 2009, 69: S23-S328 Wu Z M, Huang Z Q, Lehmann R, Zhao C X, Xu G W. Chromatographia, 2009, 69: S23-S32

    9. [9]

      9 Tang H R, Wang Y L. Prog. Biochem. Biophys., 2006, 33(5): 401-4179 Tang H R, Wang Y L. Prog. Biochem. Biophys., 2006, 33(5): 401-417

    10. [10]

      10 Heiden M G V, Cantley L C, Thompson C B. Science, 2009, 324(5930): 1029-103310 Heiden M G V, Cantley L C, Thompson C B. Science, 2009, 324(5930): 1029-1033

    11. [11]

      11 Samudio I, Fiegl M, Andreeff M. Cancer Res., 2009, 69(6): 2163-216611 Samudio I, Fiegl M, Andreeff M. Cancer Res., 2009, 69(6): 2163-2166

    12. [12]

      12 Warburg O. Science, 1956, 123(3191): 309-31412 Warburg O. Science, 1956, 123(3191): 309-314

    13. [13]

      13 Takats Z, Wiseman J M, Gologan B, Cooks R G. Science, 2004, 306(5695): 471-47313 Takats Z, Wiseman J M, Gologan B, Cooks R G. Science, 2004, 306(5695): 471-473

    14. [14]

      14 Cooks R G, Ouyang Z, Takats Z, Wiseman J M. Science, 2006, 311(5767): 1566-157014 Cooks R G, Ouyang Z, Takats Z, Wiseman J M. Science, 2006, 311(5767): 1566-1570

    15. [15]

      15 Cody R B, Laramee J A, Durst H D. Anal. Chem., 2005, 77(8): 2297-230215 Cody R B, Laramee J A, Durst H D. Anal. Chem., 2005, 77(8): 2297-2302

    16. [16]

      16 Chen H W, Venter A, Cooks R G. Chem. Commun., 2006, (19): 2042-204416 Chen H W, Venter A, Cooks R G. Chem. Commun., 2006, (19): 2042-2044

    17. [17]

      17 Gu H W, Xu N, Chen H W. Anal. Bioanal. Chem., 2012, 403(8): 2145-215317 Gu H W, Xu N, Chen H W. Anal. Bioanal. Chem., 2012, 403(8): 2145-2153

    18. [18]

      18 Broadhurst D I, Kell D B. Metabolomics, 2006, 2(4): 171-19618 Broadhurst D I, Kell D B. Metabolomics, 2006, 2(4): 171-196

    19. [19]

      19 Raftery D, Gowda G A N. J. Urol., 2008, 179(6): 2089-209019 Raftery D, Gowda G A N. J. Urol., 2008, 179(6): 2089-2090

    20. [20]

      20 Bathe O F, Shaykhutdinov R, Kopciuk K, Weljie A M, Mckay A, Sutherland F R, Dixon E, Dunse N, Sotiropoulos D, Vogel H J. Cancer Epidem. Biomar., 2011, 20(1): 140-14720 Bathe O F, Shaykhutdinov R, Kopciuk K, Weljie A M, Mckay A, Sutherland F R, Dixon E, Dunse N, Sotiropoulos D, Vogel H J. Cancer Epidem. Biomar., 2011, 20(1): 140-147

    21. [21]

      21 Odunsi K, Wollman R M, Ambrosone C B, Hutson A, McCann S E, Tammela J, Geisler J P, Miller G, Sellers T, Cliby W, Qian F, Keitz B, Intengan M, Lele S, Alderfer J L. Int. J. Cancer, 2005, 113(5): 782-78821 Odunsi K, Wollman R M, Ambrosone C B, Hutson A, McCann S E, Tammela J, Geisler J P, Miller G, Sellers T, Cliby W, Qian F, Keitz B, Intengan M, Lele S, Alderfer J L. Int. J. Cancer, 2005, 113(5): 782-788

    22. [22]

      22 Rantalainen M, Cloarec O, Beckonert O, Wilson I D, Jackson D, Tonge R, Rowlinson R, Rayner S, Nickson J, Wilkinson R W, Mills J D, Trygg J, Nicholson J K, Holmes E. J. Proteome Res., 2006, 5(10): 2642-265522 Rantalainen M, Cloarec O, Beckonert O, Wilson I D, Jackson D, Tonge R, Rowlinson R, Rayner S, Nickson J, Wilkinson R W, Mills J D, Trygg J, Nicholson J K, Holmes E. J. Proteome Res., 2006, 5(10): 2642-2655

    23. [23]

      23 Chen H W, Pan Z Z, Talaty N, Raftery D, Cooks R G. Rapid Commun. Mass Spectrom., 2006, 20(10): 1577-158423 Chen H W, Pan Z Z, Talaty N, Raftery D, Cooks R G. Rapid Commun. Mass Spectrom., 2006, 20(10): 1577-1584

    24. [24]

      24 Fan T W, Lane A N, Higashi R M, Farag M A, Gao H, Bousamra M, Miller D M. Mol. Cancer, 2009, 8: 4124 Fan T W, Lane A N, Higashi R M, Farag M A, Gao H, Bousamra M, Miller D M. Mol. Cancer, 2009, 8: 41

    25. [25]

      25 Chen J, Wang W Z, Lv S, Yin P Y, Zhao X J, Lu X, Zhang F X, Xu G W. Anal. Chim. Acta, 2009, 650(1): 3-925 Chen J, Wang W Z, Lv S, Yin P Y, Zhao X J, Lu X, Zhang F X, Xu G W. Anal. Chim. Acta, 2009, 650(1): 3-9

    26. [26]

      26 Sitter B, Lundgren S, Bathen T F, Halgunset J, Fjosne H E, Gribbestad I S. NMR Biomed., 2006, 19(1): 30-4027 Asiago V M, Alvarado L Z, Shanaiah N, Gowda G A N, Owusu-Sarfo K, Ballas R A, Raftery D. Cancer Res., 2010, 70(21): 8309-831826 Sitter B, Lundgren S, Bathen T F, Halgunset J, Fjosne H E, Gribbestad I S. NMR Biomed., 2006, 19(1): 30-4027 Asiago V M, Alvarado L Z, Shanaiah N, Gowda G A N, Owusu-Sarfo K, Ballas R A, Raftery D. Cancer Res., 2010, 70(21): 8309-8318

    27. [27]

      28 Pan Z Z, Raftery D. Anal. Bioanal.Chem., 2007, 387(2): 525-52728 Pan Z Z, Raftery D. Anal. Bioanal.Chem., 2007, 387(2): 525-527

    28. [28]

      29 Gu H W, Pan Z Z, Xi B W, Asiago V, Musselman B, Raftery D. Anal. Chim. Acta, 2011, 686(1-2): 57-6329 Gu H W, Pan Z Z, Xi B W, Asiago V, Musselman B, Raftery D. Anal. Chim. Acta, 2011, 686(1-2): 57-63

    29. [29]

      30 Wang D J, Bodovitz S. Trends Biotechnol., 2010, 28(6): 281-29030 Wang D J, Bodovitz S. Trends Biotechnol., 2010, 28(6): 281-290

    30. [30]

      31 D'Alessandro A, Zolla L. Drug Discov. Today, 2012, 17(1-2): 3-931 D'Alessandro A, Zolla L. Drug Discov. Today, 2012, 17(1-2): 3-9

    31. [31]

      32 Wishart D S, Tzur D, Knox C, Eisner R, Guo A C, Young N, Cheng D, Jewell K, Arndt D, Sawhney S, Fung C, Nikolai L, Lewis M, Coutouly M A, Forsythe I, Tang P, Shrivastava S, Jeroncic K, Stothard P, Amegbey G, Block D, Hau D D, Wagner J, Miniaci J, Clements M, Gebremedhin M, Guo N, Zhang Y, Duggan G E, MacInnis G D, Weljie A M, Dowlatabadi R, Bamforth F, Clive D, Greiner R, Li L, Marrie T, Sykes B D, Vogel H J, Querengesser L. Nucleic Acids Res., 2007, 35: D521-D52632 Wishart D S, Tzur D, Knox C, Eisner R, Guo A C, Young N, Cheng D, Jewell K, Arndt D, Sawhney S, Fung C, Nikolai L, Lewis M, Coutouly M A, Forsythe I, Tang P, Shrivastava S, Jeroncic K, Stothard P, Amegbey G, Block D, Hau D D, Wagner J, Miniaci J, Clements M, Gebremedhin M, Guo N, Zhang Y, Duggan G E, MacInnis G D, Weljie A M, Dowlatabadi R, Bamforth F, Clive D, Greiner R, Li L, Marrie T, Sykes B D, Vogel H J, Querengesser L. Nucleic Acids Res., 2007, 35: D521-D526

    32. [32]

      33 Kanehisa M. In Silico Simulation of Biological Processes, 2002, 247: 91-10333 Kanehisa M. In Silico Simulation of Biological Processes, 2002, 247: 91-103

    33. [33]

      34 http://webbook.nist.gov/chemistry/34 http://webbook.nist.gov/chemistry/

  • 加载中
计量
  • PDF下载量:  0
  • 文章访问数:  266
  • HTML全文浏览量:  24
文章相关
  • 收稿日期:  2012-05-28
  • 网络出版日期:  2012-09-26
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

/

返回文章