组氨酸、组胺醇和组胺钴(Ⅱ)配合物氧合性能的比较研究

引用本文: 张新村, 岳凡, 黄艳, 程翔, 文红梅, 胡地, 王吉德. 组氨酸、组胺醇和组胺钴(Ⅱ)配合物氧合性能的比较研究[J]. 无机化学学报, 2013, 29(11): 2387-2393. doi: 10.3969/j.issn.1001-4861.2013.00.353 shu

Citation: ZHANG Xin-Cun, YUE Fan, HUANG Yan, CHENG Xiang, WEN Hong-Mei, HU Di, WANG Ji-De. Comparative Study for Oxygenation Properties of Cobalt Complexes with Hsitidine, Histidinol and Histamine[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(11): 2387-2393. doi: 10.3969/j.issn.1001-4861.2013.00.353 shu

组氨酸、组胺醇和组胺钴(Ⅱ)配合物氧合性能的比较研究

基金项目:
国家自然科学基金(No.20961010,21162027,21261022)资助项目。 (No.20961010,21162027,21261022)

摘要: 本文用UV-Vis光谱和氧电极法对结构相似的His-Co、Hio-Co、Hit-Co₃组配合物氧合性能进行了对比研究。由配合物光谱随pH变化的A-pH曲线,可知3组配合物均在pH6.0以后开始发生氧合反应,在pH6.0~10.0的范围内His-Co有2种氧合物种生成,其他2组配合物均只有1种氧合配合物生成。用等摩尔比法对氧合配合物的组成比进行了测定,得知Co:His与Co:Hio的配位比为1:2,而Co:Hit为1:3;在室温水溶液中和pH₇的条件下,用UV-Vis在波长384nm下分别考察了3组配合物的氧合性能和它们的抗老化能力,结果表明3组配合物在室温水溶液中均可发生氧合反应,但氧合性能有很大差异,His-Co经过110h累计560次可逆循环,仍然具有5%氧合性能,而Hio、Hit分别经过59次/54h、5次/10.2h循环后氧合性能衰减至5%。3组配合物的抗老化能力的大小顺序为:His-Co>>Hio-Co>Hit-Co。研究结果初步说明:三配位原子配体配合物的可逆吸氧性能好于二配位原子配体的配合物,氨基酸配合物优于氨基醇配合物。

关键词:

钴(Ⅱ)配合物;氧合配合物;紫外可见光谱;组氨酸;组胺醇

English

Comparative Study for Oxygenation Properties of Cobalt Complexes with Hsitidine, Histidinol and Histamine

1.
Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education & Xinjiang Uygur Autonomous Region, Chemistry and Chemical Engineering of Xinjiang University, Urumqi 830046, China
Received Date: 19 December 2012
Fund Project:
国家自然科学基金(No.20961010,21162027,21261022)资助项目。

Abstract: Oxygenation of three complexes His-Co, Hio-Co and Hit-Co were determined by UV-Vis spectrophotometry and oxygen electrode, respectively. The curve of absorption change with pHshowed that the oxygenation reactions took place after pH6.0 for all three complexes. His-Co has two oxygenated species in pH6.0~10.0, whereas, Hio-Co and Hit-Co only formed one oxygenated species. The results obtained from the equimolar ratio method showed the molar ration for Co:His and Co:Hio is 1:2,whereas Co:Hit is 1:3. Oxygenation properties and anti-aging processes of three complexes were determined by UV-V is spectrophotometry at λ=384 nm in room temperature in pH 7.0, respectively. The results revealed that all three complexes can uptake dioxygen reversibly whereas there are obvious differences in their oxygenations, especially in the deoxygenation rate. His-Co kept 5% oxygenation capacity after 560 cycles/110 h continuous oxygenation, while Hio-Co and Hit-Co sustained 59 cycles/54 h and 5 cycles /10.2 h, respectively. The order of anti-aging rate of the complexes is His-Co>>Hio-Co>Hit-Co. The results suggested that the uptaking dioxygen reversibility of the complex with a ligand of three coordinating atoms is better than the complex with a ligand of two coordinating atoms, and the uptaking dioxygen reversibility of the aminoacid complex is better than that of alkamine complex.

Key words:

Co(Ⅱ) complex;oxygenated complex;UV-Vis spectrum;hsitidine;histidinol

1. [1] Niederhoffer E C, Timmons J H, Martell A E. Chem. Rev., 1984,84:137-203[1] Niederhoffer E C, Timmons J H, Martell A E. Chem. Rev., 1984,84:137-203
2. [2] Martell A E, Calvin M. Science Press, 1964:358-378[2] Martell A E, Calvin M. Science Press, 1964:358-378
3. [3] Busch D H and Alcockt N W. Chem. Rev., 1994,94:585-623[3] Busch D H and Alcockt N W. Chem. Rev., 1994,94:585-623
4. [4] Kobayashi M S. Eur. J. Biochem., 2001,261(1):1-9[4] Kobayashi M S. Eur. J. Biochem., 2001,261(1):1-9
5. [5] Yu M H, Dai M, Liu Q, et al. Cancer Treatment Reciew, 2007,33(8):757-761[5] Yu M H, Dai M, Liu Q, et al. Cancer Treatment Reciew, 2007,33(8):757-761
6. [6] Murray L J, Dinca M, Yano J. J. Am. Chem. Soc., 2010,132 (23):7856-7857[6] Murray L J, Dinca M, Yano J. J. Am. Chem. Soc., 2010,132 (23):7856-7857
7. [7] Johnson C, Ottiger S, Pini R, et al. AIChE J., 2009,55(4): 1040-1045[7] Johnson C, Ottiger S, Pini R, et al. AIChE J., 2009,55(4): 1040-1045
8. [8] Castro C I, Briceno J C. Artificial Organs, 2010,34(8):622-634[8] Castro C I, Briceno J C. Artificial Organs, 2010,34(8):622-634
9. [9] Buehler P W, Agnillo F D, Schaer D J. Trends in Molecular Medicine, 2010,16(10):447-457[9] Buehler P W, Agnillo F D, Schaer D J. Trends in Molecular Medicine, 2010,16(10):447-457
10. [10]Haber J, Matachowski L, Pamin K, et al. J. Mol. Catal. A: Chem., 2000,162(1/2):105-109[10]Haber J, Matachowski L, Pamin K, et al. J. Mol. Catal. A: Chem., 2000,162(1/2):105-109
11. [11]HAO Chao-Jun (邢朝晖), HAO Chen-Jun (郝成君). Chem. Ind. Times (Huagong shikan), 2006,20(9):7-9[11]HAO Chao-Jun (邢朝晖), HAO Chen-Jun (郝成君). Chem. Ind. Times (Huagong shikan), 2006,20(9):7-9
12. [12]Adduci J. Chem.Techonl., 1976,(9):575-580[12]Adduci J. Chem.Techonl., 1976,(9):575-580
13. [13]YIN Xiao-Chun(殷小春), WANG Rong-Min(王荣民), HE Yu-Feng(何玉凤), et al. Prog. Chem.(Huaxue Jinzhan), 2011,23(5):963-972[13]YIN Xiao-Chun(殷小春), WANG Rong-Min(王荣民), HE Yu-Feng(何玉凤), et al. Prog. Chem.(Huaxue Jinzhan), 2011,23(5):963-972
14. [14]Simplicio J, Wilkins R G. J. Am. Chem. Soc., 1967,89: 6092-6095[14]Simplicio J, Wilkins R G. J. Am. Chem. Soc., 1967,89: 6092-6095
15. [15]Harris W R, Mclendon G, Martell A E. J. Am. Chem. Soc., 1976,98:8378-8381[15]Harris W R, Mclendon G, Martell A E. J. Am. Chem. Soc., 1976,98:8378-8381
16. [16]Tiné M R. Coord. Chem. Rev., 2012,256:316-327[16]Tiné M R. Coord. Chem. Rev., 2012,256:316-327
17. [17]Shuvaev V V, Muzykantov V R. J. Controlled Release, 2011, 153(1):56-63[17]Shuvaev V V, Muzykantov V R. J. Controlled Release, 2011, 153(1):56-63
18. [18]Melchior A, Tolazzi M. Inorg. Chim. Acta, 2011,367(1):120-126[18]Melchior A, Tolazzi M. Inorg. Chim. Acta, 2011,367(1):120-126
19. [19]Keypour H, Ahmadi M, Rezaeivala M, et al. Polyhedron, 2011,30(11):1865-1870[19]Keypour H, Ahmadi M, Rezaeivala M, et al. Polyhedron, 2011,30(11):1865-1870
20. [20]FU Ji-Hong (符继红), LI Jun-Fang (李俊芳), FU Pei (付佩), et al. Chem. J. Chinese Universities (Gaogeng Xuexiao Huaxue Xuebao), 2011,32(7):1483-1487[20]FU Ji-Hong (符继红), LI Jun-Fang (李俊芳), FU Pei (付佩), et al. Chem. J. Chinese Universities (Gaogeng Xuexiao Huaxue Xuebao), 2011,32(7):1483-1487
21. [21]LI Jun-Fang (李俊芳), FU Ji-Hong (符继红), FU Pei (付佩), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2011,27(11):2225-2230[21]LI Jun-Fang (李俊芳), FU Ji-Hong (符继红), FU Pei (付佩), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2011,27(11):2225-2230
22. [22]XIAO Fu-Rong(肖芙蓉), WANG Ji-De(王吉德), YUE Fan (岳凡), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2006,22(7):1293-1298[22]XIAO Fu-Rong(肖芙蓉), WANG Ji-De(王吉德), YUE Fan (岳凡), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2006,22(7):1293-1298
23. [23]HAN Zhi-Jian(韩志坚), ZhOU Hong(周洪), ChEN Han-Wen (陈汉文), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 1992,8(4):421-426[23]HAN Zhi-Jian(韩志坚), ZhOU Hong(周洪), ChEN Han-Wen (陈汉文), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 1992,8(4):421-426
24. [24]Martell A E. Acc. Chem. Res., 1982,15:155-162[24]Martell A E. Acc. Chem. Res., 1982,15:155-162
25. [25]ZHANG Yi (张翼), WANG Ji-de (王吉德), YUE Fan (岳凡). Electrochemistry (Dian Hauxue), 2000,6(1):45-51[25]ZHANG Yi (张翼), WANG Ji-de (王吉德), YUE Fan (岳凡). Electrochemistry (Dian Hauxue), 2000,6(1):45-51
26. [26]ZHANG Xin-Cun (张新村), YUE Fan (岳凡), HUANG Yan (黄艳) et al. Chem. J. Chinese Universities (Gaogeng Xuexiao Huaxue Xuebao), 2012,33(7):1370-1375[26]ZHANG Xin-Cun (张新村), YUE Fan (岳凡), HUANG Yan (黄艳) et al. Chem. J. Chinese Universities (Gaogeng Xuexiao Huaxue Xuebao), 2012,33(7):1370-1375
27. [27]LEI Hong-Qin (雷红琴). Masters Degree Thesis of Xinjiang Uinversity (新疆大学硕士论文). 2010.[27]LEI Hong-Qin (雷红琴). Masters Degree Thesis of Xinjiang Uinversity (新疆大学硕士论文). 2010.
28. [28]SONG Na (宋娜). Masters Degree Thesis of Xinjiang Uinversity (新疆大学硕士论文). 2010.[28]SONG Na (宋娜). Masters Degree Thesis of Xinjiang Uinversity (新疆大学硕士论文). 2010.
29. [29]FU Pei (付佩), FU Ji-Hong(符继红), LI Jun-Fang(李俊芳) et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2012, 28(7):160-1364[29]FU Pei (付佩), FU Ji-Hong(符继红), LI Jun-Fang(李俊芳) et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2012, 28(7):160-1364
30. [30]Yue F, Song N, Huang Y, Wang J D, et al. Inorg. Chim. Acta, 2013,398:141-146[30]Yue F, Song N, Huang Y, Wang J D, et al. Inorg. Chim. Acta, 2013,398:141-146
31. [31]Gajda T, Henry B, Delpuech J. Inorg. Chem., 1997,36: 1850-1859[31]Gajda T, Henry B, Delpuech J. Inorg. Chem., 1997,36: 1850-1859

扫一扫看文章

计量

PDF下载量: 0
文章访问数: 401
HTML全文浏览量: 53

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

组氨酸、组胺醇和组胺钴(Ⅱ)配合物氧合性能的比较研究

English

Comparative Study for Oxygenation Properties of Cobalt Complexes with Hsitidine, Histidinol and Histamine

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

组氨酸、组胺醇和组胺钴(Ⅱ)配合物氧合性能的比较研究

English

Comparative Study for Oxygenation Properties of Cobalt Complexes with Hsitidine, Histidinol and Histamine

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs