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一种基于铜配合物的高灵敏硫化氢荧光探针

黄彬 ,  陈韵聪 ,  郭子建 ,  何卫江

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引用本文: 黄彬, 陈韵聪, 郭子建, 何卫江. 一种基于铜配合物的高灵敏硫化氢荧光探针[J]. 无机化学学报, 2013, 29(11): 2283-2288. doi: 10.3969/j.issn.1001-4861.2013.00.347 shu
Citation:  HUANG Bin, CHEN Yun-Cong, GUO Zi-Jian, HE Wei-Jiang. A New Sensitive Fluorescent H2S Probe Based on Cu2+ Complex[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(11): 2283-2288. doi: 10.3969/j.issn.1001-4861.2013.00.347 shu

一种基于铜配合物的高灵敏硫化氢荧光探针

  • 基金项目:

    国家自然科学基金(No.21271100) (No.21271100)

    重大基础研究计划(No.2011CB935800)资助项目。 (No.2011CB935800)

摘要: 作为继NO和CO之后的第三个气体信号分子,硫化氢在生物体内具有许多重要的生理功能,因此发展灵敏度高、选择性好的硫化氢荧光探针以实现其实时跟踪和检测成为研究的热点。本文利用NBD荧光配体构建了一个基于其铜配合物的硫化氢荧光探针。铜离子的荧光猝灭作用使得该配合物探针的荧光很弱,而Na2S(硫化氢供体)的加入可显著增强其荧光。研究表明其他阴离子对配合物探针的荧光影响很小,共存时也不会干扰探针对硫化氢的增强响应。研究认为S2-对铜离子(Cu2+)的高亲和能力促使配合物脱铜可能是其实现荧光增强识别的机制。该探针在1~20μmol·L-1的范围内对H2S具有线性响应能力,而且检测限可达到0.2μmol·L-1,是目前检测限较低的少数探针之一。

English

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  • 收稿日期:  2012-05-16
  • 网络出版日期:  2013-05-06
通讯作者: 陈斌, bchen63@163.com
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