基于多重氢键的寡聚芳酰胺自组装囊泡

引用本文: 贺有周, 刘云, 刘鹏, 冯文, 袁立华. 基于多重氢键的寡聚芳酰胺自组装囊泡[J]. 物理化学学报, 2014, 30(8): 1501-1508. doi: 10.3866/PKU.WHXB201406122 shu

Citation: HE You-Zhou, LIU Yun, LIU Peng, FENG Wen, YUAN Li-Hua. Self-Assembly of Vesicles from Oli aramide Based on Multiple Hydrogen Bonds[J]. Acta Physico-Chimica Sinica, 2014, 30(8): 1501-1508. doi: 10.3866/PKU.WHXB201406122 shu

基于多重氢键的寡聚芳酰胺自组装囊泡

基金项目:
国家自然科学基金（21172158)

国家自然科学基金国家基础科学人才培养基金（J1210004，J1103315）资助项目

摘要:

六重氢键的异互补寡聚芳酰胺双股分子链在自组装过程中表现出极高的顺序专一性. 本文借助扫描电镜（SEM）、透射电镜（TEM）和动态光散射（DLS）等实验手段，研究了氢键编码顺序为DADDAD-DADDAD的寡聚芳酰胺分子1及异互补分子2（ADAADA-ADAADA）存在下的自组装行为. 实验结果表明，分子1在四氢呋喃/甲醇（体积比为85/15）和单一溶剂丙酮中都能组装成大小均匀的囊泡结构，并且囊泡的尺寸随着溶液浓度的增加而增大；当加入异互补分子2后，囊泡则转变成实心球. 利用荧光显微镜，发现该囊泡能很好地包裹荧光分子（罗丹明B），通过进一步分子结构修饰有可能实现药物包埋和缓释方面的应用.

关键词:

English

Self-Assembly of Vesicles from Oli aramide Based on Multiple Hydrogen Bonds

1.
Key Laboratory for Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China
Received Date: 17 April 2014
Available Online: 18 July 2014
Fund Project:
国家自然科学基金（21172158)

国家自然科学基金国家基础科学人才培养基金（J1210004，J1103315）资助项目

Abstract:

Six-hydrogen-bonded oli aramide heteroduplexes demonstrate extremely high sequencespecificity and tunable stability during their self-assembly. The self-assembly behavior of molecular oli aramide 1 arrayed in a DADDAD-DADDAD sequence and that in the presence of oli aramide 2 with an ADAADAADAADA sequence were examined using multiple techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Results from these experiments indicate that 1 can self-assemble to vesicles with uniform shapes in both tetrahydrofuran/methanol (V/V, 85/15) and acetone, the size of which increased with an increase in solution concentration. Upon addition of the corresponding complementary 2, the vesicles turned into solid balls. Fluorescence microscopy experiments revealed that the vesicles were able to encapsulate the fluorescence molecules (Rhodamine B). With further modification of molecular structures, these vesicles may hold potential for applications as drug carrier as well as in controlled-release technology.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

基于多重氢键的寡聚芳酰胺自组装囊泡

English

Self-Assembly of Vesicles from Oli aramide Based on Multiple Hydrogen Bonds

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

基于多重氢键的寡聚芳酰胺自组装囊泡

English

Self-Assembly of Vesicles from Oli aramide Based on Multiple Hydrogen Bonds

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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