引用本文:
朱君, 钱俊红, 郭荣. 头孢唑酮与Triton X-100缔合体系的相互作用[J]. 物理化学学报,
2005, 21(03): 234-238.
doi:
10.3866/PKU.WHXB20050302
Citation: ZHU Jun, QIAN Jun-Hong, GUO Rong. Interaction of Cephanone with Triton X-100 Aggregates[J]. Acta Physico-Chimica Sinica, 2005, 21(03): 234-238. doi: 10.3866/PKU.WHXB20050302
Citation: ZHU Jun, QIAN Jun-Hong, GUO Rong. Interaction of Cephanone with Triton X-100 Aggregates[J]. Acta Physico-Chimica Sinica, 2005, 21(03): 234-238. doi: 10.3866/PKU.WHXB20050302
头孢唑酮与Triton X-100缔合体系的相互作用
摘要:
抗生素头孢唑酮的加入使得非离子表面活性剂Triton X-100的表面活性降低. 1H-NMR的结果表明，头孢唑酮增溶于胶束极性基团附近.头孢唑酮与Triton X-100胶束的结合常数随Triton X-100含量的增加而下降，但头孢唑酮在Triton X-100胶束相和水连续相之间的分配系数不随Triton X-100含量变化而变化.
English
Interaction of Cephanone with Triton X-100 Aggregates
Abstract:
The effects of cephanone on the surface activity and aggregation behavior of Triton X-100 molecule were studied by the methods of surface tension and fluorescence, respectively. The binding constant between cephanone and Triton X-100 micelles was determined by the method of steady state fluorescence. The location of cephanone in Triton X-100 micelles was investigated through nuclear magnetic spectroscopy (NMR). The results showed that the surface activity of Triton X-100 decreased with the increase of cephanone concentration. With the increase of Triton X-100 concentration, the binding constant between cephanone and Triton X-100 micelles decreased, but the distribution coefficient of cephanone between Triton X-100 micelles and water continuous phase kept being invariable. The results of 1H-NMR showed that cephanone was located around the polar group of Triton X-100 micelle.
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