引用本文:
侯安新, 屈松生, 黄伟国, 刘义. 两种稀土卟啉配合物与大肠杆菌作用的微量热研究[J]. 物理化学学报,
2003, 19(02): 134-138.
doi:
10.3866/PKU.WHXB20030209
Citation: Hou An-Xin, Qu Song-Sheng, Wong Wai-Kwok, Liu Yi. Microcalorimetric Study of the Action of Two Kinds of Lanthanide Monoporphyrinate Complexes on Growth Metabolism of Escherichia Coli[J]. Acta Physico-Chimica Sinica, 2003, 19(02): 134-138. doi: 10.3866/PKU.WHXB20030209
Citation: Hou An-Xin, Qu Song-Sheng, Wong Wai-Kwok, Liu Yi. Microcalorimetric Study of the Action of Two Kinds of Lanthanide Monoporphyrinate Complexes on Growth Metabolism of Escherichia Coli[J]. Acta Physico-Chimica Sinica, 2003, 19(02): 134-138. doi: 10.3866/PKU.WHXB20030209
两种稀土卟啉配合物与大肠杆菌作用的微量热研究
摘要:
用LKB-2277生物活性检测系统测定了新合成的阳离子型稀土卟啉配合物{[Re(TMP)(H2O)3]Cl, Re=Y、Yb, TMP=5, 10, 15, 20-四(4’-甲氧基苯基)卟啉}在37 ℃时对大肠杆菌作用的产热曲线,根据产热曲线求算了在稀土卟啉配合物作用下,大肠杆菌生长代谢的速率常数k,抑制率I,传代时间tG和半抑制浓度cI,50等热动力学参数.结果表明,稀土卟啉配合物在低浓度下对大肠杆菌有刺激作用,高浓度下为抑制作用,[Yb(TMP)(H2O)3]Cl的半抑制浓度cI,50为143 mg•L-1,其对大肠杆菌的抑制作用优于[Y(TMP)(H2O)3]Cl.
English
Microcalorimetric Study of the Action of Two Kinds of Lanthanide Monoporphyrinate Complexes on Growth Metabolism of Escherichia Coli
Abstract:
The biothermochemical characteristics of the actions of two kinds of cationic lanthanide(III) monoporphyrinate complexes {[Re(TMP)(H2O)3]Cl, Re=Y, Yb, TMP=5,10,15,20 -tetrakis(4’-methoxyphenyl)porphyrin} on growth metabolism of Escherichia coli were studied by means of a LKB-2277 bioactivity monitor at 37 ℃.The maximum power, Pmax; the growth rate constant k1,k2; inhibitive ratio I(％) and half inhibition concentration cI,50 (mg•L-1),respectively, were obtained. Experimental results show that porphyrinate complexes possess the bi-directional biological effection: they stimulate the growth of the E. coli at lower concentration but inhibit the growth at higher concentration. Inhibitory effection of [Yb(TMP)(H2O)3]Cl (cI,50=143 mg•L-1) is stronger than that of [Y(TMP)(H2O)3]Cl.
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