引用本文:
Jin Ming Zhang, Jia He Tian, Tian Ran Li, Hai Yu Guo, Li Shen. 99mTc-AMD3100:A novel potential receptor-targeting radiopharmaceutical for tumor imaging[J]. Chinese Chemical Letters,
2010, 21(4): 461-463.
doi:
10.1016/j.cclet.2009.12.018
Citation: Jin Ming Zhang, Jia He Tian, Tian Ran Li, Hai Yu Guo, Li Shen. 99mTc-AMD3100:A novel potential receptor-targeting radiopharmaceutical for tumor imaging[J]. Chinese Chemical Letters, 2010, 21(4): 461-463. doi: 10.1016/j.cclet.2009.12.018
Citation: Jin Ming Zhang, Jia He Tian, Tian Ran Li, Hai Yu Guo, Li Shen. 99mTc-AMD3100:A novel potential receptor-targeting radiopharmaceutical for tumor imaging[J]. Chinese Chemical Letters, 2010, 21(4): 461-463. doi: 10.1016/j.cclet.2009.12.018
99mTc-AMD3100:A novel potential receptor-targeting radiopharmaceutical for tumor imaging
摘要:
The chemokine CXCR4 receptor is over-expressed in a wide variety of tumors.AMD3100,which was a prototypenon-peptide antagonist of CXCR4 receptor,was labeled with 99mTC.99mTC-AMD3100 was verified by thin layer radiochromatography (TLRC).The tumor-localizing properties of 99mTc-AMD3100 were evaluated and proved in mice bearing Hep-G2 tumor xenograft.99mTc-AMD3100 was a promising,novel receptor-specific radiopharmaceutical with potentialapplication in the imaging of human tumors.
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关键词:
- 99mTc
- / Chemokine
- / CXCR4
- / AMD3100
- / Tumor imaging
English
99mTc-AMD3100:A novel potential receptor-targeting radiopharmaceutical for tumor imaging
Abstract:
The chemokine CXCR4 receptor is over-expressed in a wide variety of tumors.AMD3100,which was a prototypenon-peptide antagonist of CXCR4 receptor,was labeled with 99mTC.99mTC-AMD3100 was verified by thin layer radiochromatography (TLRC).The tumor-localizing properties of 99mTc-AMD3100 were evaluated and proved in mice bearing Hep-G2 tumor xenograft.99mTc-AMD3100 was a promising,novel receptor-specific radiopharmaceutical with potentialapplication in the imaging of human tumors.
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Key words:
- 99mTc
- / Chemokine
- / CXCR4
- / AMD3100
- / Tumor imaging
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