引用本文:
Jin Gang YU, Ke Long HUANG, Du Shu HUANG, Jin Yue PU. Synthesis of Hydroxypropyl-β-cyclodextrin Bonded Silica-gel and its Application to Resolution[J]. Chinese Chemical Letters,
2006, 17(12): 1547-1550.
Citation: Jin Gang YU, Ke Long HUANG, Du Shu HUANG, Jin Yue PU. Synthesis of Hydroxypropyl-β-cyclodextrin Bonded Silica-gel and its Application to Resolution[J]. Chinese Chemical Letters, 2006, 17(12): 1547-1550.
Citation: Jin Gang YU, Ke Long HUANG, Du Shu HUANG, Jin Yue PU. Synthesis of Hydroxypropyl-β-cyclodextrin Bonded Silica-gel and its Application to Resolution[J]. Chinese Chemical Letters, 2006, 17(12): 1547-1550.
Synthesis of Hydroxypropyl-β-cyclodextrin Bonded Silica-gel and its Application to Resolution
摘要:
In order to set up a simple and effective method for resolution of optical isomers, hydroxypropyl-β-cyclodextrin was bonded to silica-gel, which can be used for preparation of thin-layer chromatography plates. Resolution of clenbuterol and propranolol were investigated on these thin-layer chromatography plates using different combinations of solvent systems at ambient temperature. The best simultaneous resolution was achieved in solvent system of acetonitrile-n-butanol (50:50, v/v). Rst values of resolution of clenbuterol hydrochloride and propranolol hydrochloride are 3.6 and 4.3, respectively. The spots of different enantiomers are separated clearly. The results showed that hydroxypropyl-β-cyclodextrin bonded silica-gel could be successful in resolution of chiral adrenergic drugs. The study offers a direct, rapid and reliable method for separation of this kind of optically active compounds.
English
Synthesis of Hydroxypropyl-β-cyclodextrin Bonded Silica-gel and its Application to Resolution
Abstract:
In order to set up a simple and effective method for resolution of optical isomers, hydroxypropyl-β-cyclodextrin was bonded to silica-gel, which can be used for preparation of thin-layer chromatography plates. Resolution of clenbuterol and propranolol were investigated on these thin-layer chromatography plates using different combinations of solvent systems at ambient temperature. The best simultaneous resolution was achieved in solvent system of acetonitrile-n-butanol (50:50, v/v). Rst values of resolution of clenbuterol hydrochloride and propranolol hydrochloride are 3.6 and 4.3, respectively. The spots of different enantiomers are separated clearly. The results showed that hydroxypropyl-β-cyclodextrin bonded silica-gel could be successful in resolution of chiral adrenergic drugs. The study offers a direct, rapid and reliable method for separation of this kind of optically active compounds.
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