不对称二亚胺席夫碱的合成、表征和抗菌活性

引用本文: Nartop Dilek, Gürkan Perihan. 不对称二亚胺席夫碱的合成、表征和抗菌活性[J]. 无机化学学报, 2013, 29(6): 1227-1234. doi: 10.3969/j.issn.1001-4861.2013.00.227 shu

Citation: Nartop Dilek, Gürkan Perihan. Synthesis, Characterization and Antibacterial Activities of Unsymmetric Diimine Schiff Bases and Their Fe(Ⅲ) and Ni(Ⅱ) Complexes[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(6): 1227-1234. doi: 10.3969/j.issn.1001-4861.2013.00.227 shu

不对称二亚胺席夫碱的合成、表征和抗菌活性

Nartop Dilek ^1, ,
Gürkan Perihan ^2,

基金项目:
Gazi Universtiy Research foundations资助项目(Supported by Gazi Universtiy Research foundations(FEF 05/2003-64) (Supported by Gazi Universtiy Research foundations(FEF 05/2003-64)

(FEF 05/2005-37))。 (FEF 05/2005-37))

摘要: 用两步法合成了3种不对称二亚胺L,L_Me和L_Cl。起始原料席夫碱2-羟基-N-(5-硝基糠叉)苯胺(SB-NO₂)用5-硝基糠醛和2-羟基苯胺反应制得。SB-NO₂然后在溶液中被还原为其氨基衍生物SB-NH₂。在SB-NH₂溶液中分别加入2-羟基苯甲醛,2-羟基-5-甲基苯甲醛和2-羟基-5-氯苯甲醛制得二亚胺化合物L,L_Me and L_Cl。同时还合成了这些配体的Fe(Ⅲ) and Ni(Ⅱ)的二聚和双核配合物。用元素分析、LC-MS、IR、UV-Vis、¹H and ¹³C-NMR、TGA、电导率和磁性测量等对二亚胺及其配合物进行了表征,还研究了席夫碱配体及其配合物对5种细菌的抗菌活性。所有化合物对大肠埃布氏菌、枯草芽孢杆菌、小肠结肠炎耶尔森氏菌均有中等强度的活性。Fe(Ⅲ)配合物对绿脓假单胞菌(绿脓杆菌)具有最高活性。

关键词:

不对称席夫碱;Fe(Ⅲ) and Ni(Ⅱ)配合物;还原;抗菌活性

English

Synthesis, Characterization and Antibacterial Activities of Unsymmetric Diimine Schiff Bases and Their Fe(Ⅲ) and Ni(Ⅱ) Complexes

Nartop Dilek ^1, ,
Gürkan Perihan ^2,

1.
1. Department of Chemistry, Faculty of Arts and Science, Nevsehir University, Nevsehir 50300, Turkey;
Received Date: 15 February 2013
Fund Project:
Gazi Universtiy Research foundations资助项目(Supported by Gazi Universtiy Research foundations(FEF 05/2003-64)

(FEF 05/2005-37))。

Abstract: Three new unsymmetric diimines L, L_Me and L_Cl were synthesized by a two-step process. Initially, the starting Schiff base 2-hydroxy-N-(5-nitrofurylidene)aniline (SB-NO₂) was obtained by using 5-nitro-furfural and 2-hydroxyaniline. Nitro group of SB-NO₂ was reduced into its amino derivative, SB-NH₂, in solution. Diimines L, L_Me and L_Cl were obtained with the addition of 2-hydroxybenzaldehyde, 2-hydroxy-5-methylbenzaldehyde and 2-hydroxy-5-chlorobenzaldehyde, respectively, into SB-NH₂ solution. Dimeric, binuclear Fe(Ⅲ) and Ni(Ⅱ) complexes of these ligands were also synthesized. Diimines and their complexes were characterized by elemental analyses, LC-MS, IR, electronic spectra, ¹H and ¹³C-NMR spectra, TGA, conductivity and magnetic measurements. The antibacterial activities of the ligands and the complexes were investigated against five bacteria. All of the compounds showed moderate activities against Escherichia coli, Bacillus subtilis and Yersinia enterecolitica. The highest activity values were obtained by Fe(Ⅲ) complexes against Pseudomonas aeruginosa.

Key words:

unsymmetric Schiff bases;Fe(Ⅲ) and Ni(Ⅱ) complexes;reduction;antimicrobial activities

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不对称二亚胺席夫碱的合成、表征和抗菌活性

English

Synthesis, Characterization and Antibacterial Activities of Unsymmetric Diimine Schiff Bases and Their Fe(Ⅲ) and Ni(Ⅱ) Complexes

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通讯作者: 陈斌, bchen63@163.com

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不对称二亚胺席夫碱的合成、表征和抗菌活性

English

Synthesis, Characterization and Antibacterial Activities of Unsymmetric Diimine Schiff Bases and Their Fe(Ⅲ) and Ni(Ⅱ) Complexes

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

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CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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