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2-羧基苯甲醛缩二乙烯三胺钙(Ⅱ)配合物的合成、结构表征和抗肿瘤活性的研究

台夕市 ,  赵文华 ,  李法辉

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引用本文: 台夕市, 赵文华, 李法辉. 2-羧基苯甲醛缩二乙烯三胺钙(Ⅱ)配合物的合成、结构表征和抗肿瘤活性的研究[J]. 无机化学学报, 2013, 29(6): 1328-1332. doi: 10.3969/j.issn.1001-4861.2013.00.202 shu
Citation:  TAI Xi-Shi, ZHAO Wen-Hua, LI Fa-Hui. Synthesis, Structural Characterization and Antitumor Activity of a Ca(Ⅱ)-Schiff Base Complex[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(6): 1328-1332. doi: 10.3969/j.issn.1001-4861.2013.00.202 shu

2-羧基苯甲醛缩二乙烯三胺钙(Ⅱ)配合物的合成、结构表征和抗肿瘤活性的研究

  • 基金项目:

    国家自然科学基金(No.21171132 

    No.20671073) 

    山东省优秀中青年科学家奖励基金(No.2010BSA07004) (No.2010BSA07004)

    潍坊市鸢都学者岗位团队项目 和潍坊市科技发展计划资助项目。 

摘要: 在乙醇溶剂中,以高氯酸钙、2-羧基苯甲醛缩二乙烯三胺为原料,合成了一个新型钙配合物。对其进行了元素分析、红外光谱分析、摩尔电导、差热-热重分析,并用X-射线单晶衍射测定了它的单晶结构。结果表明:在配合物分子中,每个钙原子分别与希夫碱配体中的6个氧原子配位,形成了变形的八面体构型。配合物属三方晶系,P31c空间群,配合物分子通过氢键和苯环的π-π堆积作用形成了三维网状结构。初步研究了配合物对肝癌、肺腺癌、白血病和结肠癌的抗肿瘤活性。

English

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  • 收稿日期:  2012-06-17
  • 网络出版日期:  2013-02-01
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