一对手性Salen型席夫碱对映体的合成、结构与生物活性

郝洪庆 李鑫 孙静

引用本文: 郝洪庆, 李鑫, 孙静. 一对手性Salen型席夫碱对映体的合成、结构与生物活性[J]. 无机化学学报, 2013, 29(6): 1222-1226. doi: 10.3969/j.issn.1001-4861.2013.00.174 shu
Citation:  HAO Hong-Qing, LI Xin, SUN Jing. Synthesis, Structures and Biological Activities of Chiral Salen-Type Schiff Base Enantiomers[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(6): 1222-1226. doi: 10.3969/j.issn.1001-4861.2013.00.174 shu

一对手性Salen型席夫碱对映体的合成、结构与生物活性

  • 基金项目:

    国家自然科学基金(No.21101077) (No.21101077)

    广东省自然科学基金(No. S2011040001705)资助项目。 (No. S2011040001705)

摘要: 采取分步反应法以1R, 2R-环己二胺(或1S, 2S-环己二胺)与2-羟基萘甲醛和水杨酸苯酯反应,合成了一对手性Salen型席夫碱对映体:1R-(2-羟基苯甲酰亚胺)-2R-(2-羟基萘甲亚胺)环己烷(1a)和1S-(2-羟基苯甲酰亚胺)-2S-(2-羟基萘甲亚胺)环己烷(1b),对其进行了单晶结构、圆二色光谱、元素分析、红外光谱表征及生物活性实验。单晶结构与圆二色光谱分析表明1a1b互为对映体;生物活性实验显示1a具有一定的抑菌活性。

English

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  • 收稿日期:  2012-06-24
  • 网络出版日期:  2013-01-04
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