酰腙氧钒(Ⅴ)配合物的合成、结构及其抑制幽门螺旋杆菌脲酶研究

引用本文: 赵月, 韩笑, 周晓霞, 李海华, 由忠录. 酰腙氧钒(Ⅴ)配合物的合成、结构及其抑制幽门螺旋杆菌脲酶研究[J]. 无机化学学报, 2013, 29(4): 867-874. doi: 10.3969/j.issn.1001-4861.2013.00.140 shu

Citation: ZHAO Yue, HAN Xiao, ZHOU Xiao-Xia, LI Hai-Hua, YOU Zhong-Lu. Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(Ⅴ) Complexes with Hydrazones[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(4): 867-874. doi: 10.3969/j.issn.1001-4861.2013.00.140 shu

酰腙氧钒(Ⅴ)配合物的合成、结构及其抑制幽门螺旋杆菌脲酶研究

赵月 ^1, ,
韩笑 ^2, ,
周晓霞 ^1, ,
李海华 ^1, ,
由忠录 ^1,

基金项目:
国家自然科学基金(No.20901036) (No.20901036)

辽宁省高校优秀青年人才支持计划(No.LJQ2011114)资助项目。 (No.LJQ2011114)

摘要: 为了探索新型高效脲酶抑制剂, 本文合成了2个新的酰腙氧钒(Ⅴ)配合物, [VOL¹(OCH₃)(CH₃OH)] (1)和[VOL₂(μ-OCH₃)]₂ (2)(H₂L¹=N′-(5-氯-2-羟基苯亚甲基)-3-硝基苯甲酰肼;H₂L₂=N′-(5-氯-2-羟基苯亚甲基)-4-氯苯甲酰肼), 并通过物理化学方法和单晶X-射线衍射表征了它们的结构。化合物1是一个单核配合物, 而化合物2是由两个甲氧基配体桥连的具有中心对称性的双核配合物。在每个配合物中, V原子都采取八面体配位构型。本文还研究了这两个配合物的热稳定性和它们对幽门螺旋杆菌脲酶的抑制活性。在浓度为100 μmol·L^-1时, 配合物1和2对脲酶的抑制率分别为71.4%和73.3%, 其IC₅₀值分别为63.6和37.7 μmol·L^-1。

关键词:

酰腙;钒氧(Ⅴ)配合物;晶体结构;脲酶;抑制剂

English

Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(Ⅴ) Complexes with Hydrazones

1.
1 Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China;
Received Date: 27 December 2012
Fund Project:
国家自然科学基金(No.20901036)

辽宁省高校优秀青年人才支持计划(No.LJQ2011114)资助项目。

Abstract: In order to explore new and efficient urease inhibitors, two new oxovanadium(Ⅴ) complexes, [VOL¹(OCH₃)(CH₃OH)] (1) and [VOL₂(μ-OCH₃)]₂ (2) (H₂L¹=N′-(5-chloro-2-hydroxybenzylidene)-3-nitrobenzohydrazide; H₂L₂=N′-(5-chloro-2-hydroxybenzylidene)-4-chlorobenzohydrazide), have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. Compound 1 is a mononuclear complex, and compound 2 is a bis-methanolato bridged centrosymmetric dinuclear complex. The V atom in each complex adopts an octahedral coordination. Thermal stability and urease inhibitory activities of the complexes were studied. The percent inhibition at the concentration of 100 μmol·L^-1 on Helicobacter pylori urease is 71.4% for 1 and 73.3% for 2. The IC₅₀ values for 1 and 2 are 63.6 and 37.7 μmol·L^-1, respectively. CCDC: 858857, 1; and 858858, 2.

Key words:

hydrazone;oxovanadium(Ⅴ) complex;crystal structure;urease;inhibitor

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

酰腙氧钒(Ⅴ)配合物的合成、结构及其抑制幽门螺旋杆菌脲酶研究

English

Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(Ⅴ) Complexes with Hydrazones

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

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CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

酰腙氧钒(Ⅴ)配合物的合成、结构及其抑制幽门螺旋杆菌脲酶研究

English

Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(Ⅴ) Complexes with Hydrazones

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

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