琼脂糖基类丁二炔凝胶剂量计的辐照响应行为

引用本文: 陈建, 王潇, 李磊, 曾光, 孙鹏, 黄玮. 琼脂糖基类丁二炔凝胶剂量计的辐照响应行为[J]. 物理化学学报, 2016, 32(4): 1012-1018. doi: 10.3866/PKU.WHXB201601045 shu

Citation: CHEN Jian, WANG Xiao, LI Lei, ZENG Guang, SUN Peng, HUANG Wei. Radiation Response Behavior of a Diacetylene/Agarose Gel Dosimeter[J]. Acta Physico-Chimica Sinica, 2016, 32(4): 1012-1018. doi: 10.3866/PKU.WHXB201601045 shu

琼脂糖基类丁二炔凝胶剂量计的辐照响应行为

陈建 ^1, ,
王潇 ^1,2, ,
李磊 ^1, ,
曾光 ^1, ,
孙鹏 ^3, ,
黄玮 ^{1,
,}

1.
1. 中国工程物理研究院核物理与化学研究所, 四川绵阳 621900;
2.
2. 中国工程物理研究院机械制造工艺研究所, 四川绵阳 621900;
3.
3. 四川大学原子核科学技术研究所, 成都 610064

通讯作者: 黄玮

基金项目:
中国工程物理研究院科学技术发展基金(2013B0301035) (2013B0301035)

国家自然科学基金(81301934)资助项目 (81301934)

摘要: 将类丁二炔(10,12-二十五碳二炔酸)囊泡固载于琼脂糖凝胶制备出了新型辐射变色凝胶复合凝胶材料。利用γ 射线辐照研究了所制备凝胶的辐照响应行为,结果显示:当γ 辐射剂量在500-2000 Gy内,随着剂量增加,凝胶由无色逐渐变为蓝色,颜色不断加深,采用紫外-可见光分光光度计测试其吸收光谱,发现其主要吸收峰值在660 nm 附近,且辐照前后凝胶的吸光度差值与剂量有良好线性关系(相关系数R² =0.9942)。进一步研究表明:所制备的凝胶材料对γ 射线和电子束辐照有相同的剂量响应,且无明显的能量和剂量率依赖性;凝胶的辐射后效应较弱,辐照后24 h,吸光度基本恒定;分次辐照对凝胶剂量计准确性的影响极小;凝胶在0-30℃范围内的响应性基本保持稳定;在辐照后48 h 内,并未观察到囊泡有明显扩散效应,显示出良好的稳定性。此外,琼脂糖具有价廉、无毒且易制备为任意形状凝胶的优点,因此该凝胶剂量计有望应用于真实场景的三维剂量分布测定。

关键词:

English

Radiation Response Behavior of a Diacetylene/Agarose Gel Dosimeter

CHEN Jian ^1, ,
WANG Xiao ^1,2, ,
LI Lei ^1, ,
ZENG Guang ^1, ,
SUN Peng ^3, ,
HUANG Wei ^{1,
,}

1.
1. Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900, Sichuan Province, P. R. China;
2.
2. Institute of Mechanical Manufacturing Technology, China Academy of Engineering Physics, Mianyang 621900, Sichuan Province, P. R. China;
3.
3. Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, P. R. China

Corresponding author: 黄玮

Received Date: 28 September 2015
Available Online: 04 January 2016
Fund Project:
中国工程物理研究院科学技术发展基金(2013B0301035)

国家自然科学基金(81301934)资助项目

Abstract: A new diacetylene/agarose gel dosimeter composed of agarose gel as the carrier and diacetylene (10,12-pentacosadiynoic acid) vesicles as the radiochromic agent was prepared and its response behavior to γ-radiation was studied. Ultraviolet-visible spectra showed that the main absorption peak was around 660 nm, and there was a distinct linear relationship (correlation coefficient R² = 0.9942) between the absorbed dose and absorbance at 660 nm over the absorbed dose range from 500 to 2000 Gy. The diacetylene/agarose gel dosimeter exhibited the same dose response to γ-radiation and an electron beam without energy and dose rate dependency. Furthermore, the effects of temperature, diffusion, fractionated irradiation, and post-radiation on the dosimeter response were carefully investigated. The developed diacetylene/agarose gel dosimeter shows promise to measure the three-dimensional space dose within the range of 500-2000 Gy.

Key words:

1. [1]
  (1) Gore, J. C.; Kang, Y. S. Phys. Med. Biol. 1984, 29 (10), 1189. doi: 10.1088/0031-9155/29/10/002(1) Gore, J. C.; Kang, Y. S. Phys. Med. Biol. 1984, 29 (10), 1189. doi: 10.1088/0031-9155/29/10/002
2. [2]
  (2) Du, Y.;Wang, X. G. Atomic Energy Science and Technology 2014, 48 (8), 1527. [杜乙, 王贤刚. 原子能科学与技术, 2014, 48 (8), 1527.](2) Du, Y.;Wang, X. G. Atomic Energy Science and Technology 2014, 48 (8), 1527. [杜乙, 王贤刚. 原子能科学与技术, 2014, 48 (8), 1527.]
3. [3]
  (3) Baldock, C.; De Deene, Y.; Doran, S.; Ibbott, G.; Jirasek, A.; Lepage, M.; McAuley, K. B.; Oldham, M.; Schreiner, L. J. Phys. Med. Biol. 2010, 55 (5), R1. doi: 10.1088/0031-9155/55/5/R01(3) Baldock, C.; De Deene, Y.; Doran, S.; Ibbott, G.; Jirasek, A.; Lepage, M.; McAuley, K. B.; Oldham, M.; Schreiner, L. J. Phys. Med. Biol. 2010, 55 (5), R1. doi: 10.1088/0031-9155/55/5/R01
4. [4]
  (4) Fong, P. M.; Keil, D. C.; Does, M. D.; Gore, J. C. Phys. Med. Biol. 2001, 46, 3105. doi: 10.1088/0031-9155/46/12/303(4) Fong, P. M.; Keil, D. C.; Does, M. D.; Gore, J. C. Phys. Med. Biol. 2001, 46, 3105. doi: 10.1088/0031-9155/46/12/303
5. [5]
  (5) Jordan, K.; Avvakumov, N. Phys. Med. Biol. 2009, 54 (22), 6773. doi: 10.1088/0031-9155/54/22/002(5) Jordan, K.; Avvakumov, N. Phys. Med. Biol. 2009, 54 (22), 6773. doi: 10.1088/0031-9155/54/22/002
6. [6]
  (6) Babic, S.; Battista, J.; Jordan, K. Phys. Med. Biol. 2009, 54 (22), 6791. doi: 10.1088/0031-9155/54/22/003(6) Babic, S.; Battista, J.; Jordan, K. Phys. Med. Biol. 2009, 54 (22), 6791. doi: 10.1088/0031-9155/54/22/003
7. [7]
  (7) Adamovics, J.; Maryanski, M. Radiat. Prot. Dosim. 2006, 120 (1-4), 107. doi: 10.1093/rpd/nci555(7) Adamovics, J.; Maryanski, M. Radiat. Prot. Dosim. 2006, 120 (1-4), 107. doi: 10.1093/rpd/nci555
8. [8]
  (8) Vandecasteele, J.; Ghysel, S.; Baete, S.; de Deene, Y. Phys. Med. Biol. 2011, 56 (3), 627. doi: 10.1088/0031-9155/56/3/007(8) Vandecasteele, J.; Ghysel, S.; Baete, S.; de Deene, Y. Phys. Med. Biol. 2011, 56 (3), 627. doi: 10.1088/0031-9155/56/3/007
9. [9]
  (9) Lu, S.; Jia, C.; Duan, X.; Zhang, X.; Luo, F.; Han, Y.; Huang, H. Colloid Surface A 2014, 443, 488. doi: 10.1016/j.colsurfa.2013.11.029(9) Lu, S.; Jia, C.; Duan, X.; Zhang, X.; Luo, F.; Han, Y.; Huang, H. Colloid Surface A 2014, 443, 488. doi: 10.1016/j.colsurfa.2013.11.029
10. [10]
  (10) Chanakul, A.; Traiphol, N.; Faisadcha, K.; Traiphol, R. J. Colloid Interface Sci. 2014, 418, 43. doi: 10.1016/j.jcis.2013.11.083(10) Chanakul, A.; Traiphol, N.; Faisadcha, K.; Traiphol, R. J. Colloid Interface Sci. 2014, 418, 43. doi: 10.1016/j.jcis.2013.11.083
11. [11]
  (11) McLaughlin, W. L.; Chen, Y. D.; Soares, C. G.; Miller, A.; van Dyk, G.; Lewis, D. F. Nucl. Instrum. Meth. A 1991, 302 (1), 165. doi: 10.1016/0168-9002(91)90506-L(11) McLaughlin, W. L.; Chen, Y. D.; Soares, C. G.; Miller, A.; van Dyk, G.; Lewis, D. F. Nucl. Instrum. Meth. A 1991, 302 (1), 165. doi: 10.1016/0168-9002(91)90506-L
12. [12]
  (12) Butson, M. J.; Yu, P. K. N.; Cheung, T.; Metcalfe, P. Mat. Sci. Eng. R 2003, 41 (3), 61. doi: 10.1016/S0927-796X(03)00034-2(12) Butson, M. J.; Yu, P. K. N.; Cheung, T.; Metcalfe, P. Mat. Sci. Eng. R 2003, 41 (3), 61. doi: 10.1016/S0927-796X(03)00034-2
13. [13]
  (13) Liu, Q.; Jiang, B.; He, J.; Sun, P.; Zheng, D.;Wan, Y. P.; Liu, L. B. High Power Laser and Particle Beams 2008, 20 (12), 2078. [刘强, 蒋波, 何婕, 孙鹏, 郑丹, 万渝平, 刘理彬. 强激光与粒子束, 2008, 20 (12), 2078.](13) Liu, Q.; Jiang, B.; He, J.; Sun, P.; Zheng, D.;Wan, Y. P.; Liu, L. B. High Power Laser and Particle Beams 2008, 20 (12), 2078. [刘强, 蒋波, 何婕, 孙鹏, 郑丹, 万渝平, 刘理彬. 强激光与粒子束, 2008, 20 (12), 2078.]
14. [14]
  (14) Sun, P.; Jiang, B.; He, J.; Liu, Q.; Zheng, D.; Liu, L. B. Nucl. Tech. 2009, 32 (4), 273. [孙鹏, 蒋波, 何婕, 刘强, 郑丹, 刘理彬. 核技术, 2009, 32 (4), 273.](14) Sun, P.; Jiang, B.; He, J.; Liu, Q.; Zheng, D.; Liu, L. B. Nucl. Tech. 2009, 32 (4), 273. [孙鹏, 蒋波, 何婕, 刘强, 郑丹, 刘理彬. 核技术, 2009, 32 (4), 273.]
15. [15]
  (15) Lee, K. Y.; Mooney, D. J. Chem. Rev. 2001, 101 (7), 1869. doi: 10.1021/cr000108x(15) Lee, K. Y.; Mooney, D. J. Chem. Rev. 2001, 101 (7), 1869. doi: 10.1021/cr000108x
16. [16]
  (16) Wang, X.; Ao, Y. Y.; Huang, W.; Liu, B.; An, Y.; Zhai, M. L. Nucl. Sci. Tech. 2015, 26, 050304. doi: 10.13538/j.1001-8042/nst.26.050304(16) Wang, X.; Ao, Y. Y.; Huang, W.; Liu, B.; An, Y.; Zhai, M. L. Nucl. Sci. Tech. 2015, 26, 050304. doi: 10.13538/j.1001-8042/nst.26.050304
17. [17]
  (17) Wang, X.; Ao, Y. Y.; Zhao, Y.; Sun, P.; Huang, W. Atomic Energy Science and Technology 2015, (accepted). [王潇, 敖银勇, 赵岩, 孙鹏, 黄玮. 原子能科学技术, 2015, (已接收).](17) Wang, X.; Ao, Y. Y.; Zhao, Y.; Sun, P.; Huang, W. Atomic Energy Science and Technology 2015, (accepted). [王潇, 敖银勇, 赵岩, 孙鹏, 黄玮. 原子能科学技术, 2015, (已接收).]
18. [18]
  (18) Al-Sheikhly, M.; McLaughlin, W. L.; Kovacs, A.;Wojnarovits, L.; Christou, C. A.; Christou, A.; Lewis, D. F. Int. Soc. Opt. Photonic. 1997, 3005, 184. doi: 10.1117/12.271086(18) Al-Sheikhly, M.; McLaughlin, W. L.; Kovacs, A.;Wojnarovits, L.; Christou, C. A.; Christou, A.; Lewis, D. F. Int. Soc. Opt. Photonic. 1997, 3005, 184. doi: 10.1117/12.271086
19. [19]
  (19) Li, H. Z.; Xiao, Z. H.; Lin, M.; Cui, Y.; Chen, K. S.; Ye, H. S. Atomic Energy Science and Technology 2008, 42 (3), 253. [李华芝, 肖振红, 林敏, 崔莹, 陈克胜, 叶宏生. 原子能科学技术, 2008, 42 (3), 253.](19) Li, H. Z.; Xiao, Z. H.; Lin, M.; Cui, Y.; Chen, K. S.; Ye, H. S. Atomic Energy Science and Technology 2008, 42 (3), 253. [李华芝, 肖振红, 林敏, 崔莹, 陈克胜, 叶宏生. 原子能科学技术, 2008, 42 (3), 253.]
20. [20]
  (20) de Deene, Y.; Venning, A.; Hurley, C.; Healy, B.; Baldock, C. Phys. Med. Biol. 2002, 47 (14), 2459. doi: 10.1088/0031-9155/47/14/307(20) de Deene, Y.; Venning, A.; Hurley, C.; Healy, B.; Baldock, C. Phys. Med. Biol. 2002, 47 (14), 2459. doi: 10.1088/0031-9155/47/14/307
21. [21]
  (21) Sun, X.; Chen, T.; Huang, S.; Li, L.; Peng, H. Chem. Soc. Rev. 2010, 39 (11), 4244. doi: 10.1039/c001151g(21) Sun, X.; Chen, T.; Huang, S.; Li, L.; Peng, H. Chem. Soc. Rev. 2010, 39 (11), 4244. doi: 10.1039/c001151g
22. [22]
  (22) Lauher, J.W.; Fowler, F.W.; Goroff, N. S. Accounts Chem. Res. 2008, 41 (9), 1215. doi: 10.1021/ar8001427(22) Lauher, J.W.; Fowler, F.W.; Goroff, N. S. Accounts Chem. Res. 2008, 41 (9), 1215. doi: 10.1021/ar8001427

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沈阳化工大学材料科学与工程学院沈阳 110142

琼脂糖基类丁二炔凝胶剂量计的辐照响应行为

通讯作者: 黄玮

English

Radiation Response Behavior of a Diacetylene/Agarose Gel Dosimeter

Corresponding author: 黄玮

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

琼脂糖基类丁二炔凝胶剂量计的辐照响应行为

通讯作者: 黄玮

English

Radiation Response Behavior of a Diacetylene/Agarose Gel Dosimeter

Corresponding author: 黄玮

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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