壳聚糖-纤维素硫酸钠聚电解质复合物膜对药物表观渗透系数的测试

引用本文: 朱丽英, 晏晓琴, 张红漫, 林东强, 姚善泾, 江凌. 壳聚糖-纤维素硫酸钠聚电解质复合物膜对药物表观渗透系数的测试[J]. 物理化学学报, 2014, 30(2): 365-370. doi: 10.3866/PKU.WHXB201312091 shu

Citation: ZHU Li-Ying, YAN Xiao-Qin, ZHANG Hong-Man, LIN Dong-Qiang, YAO Shan-Jing, JIANG Ling. Determination of Apparent Drug Permeability Coefficients through Chitosan-Sodium Cellulose Sulfate Polyelectrolyte Complex Films[J]. Acta Physico-Chimica Sinica, 2014, 30(2): 365-370. doi: 10.3866/PKU.WHXB201312091 shu

壳聚糖-纤维素硫酸钠聚电解质复合物膜对药物表观渗透系数的测试

基金项目:
江苏省自然科学基金(BK20131406，BK20130917) (BK20131406，BK20130917)

国家自然科学基金(21106064)资助项目 (21106064)

摘要:

药物渗透系数是考察复合物膜的药物释放性能的重要参数. 本文以溶解性不同的两种药物扑热息痛和5-氨基水杨酸(5-ASA)为模型药物研究了其在壳聚糖-纤维素硫酸钠聚电解质复合物膜中的渗透性能. 结果表明：壳聚糖-纤维素硫酸钠聚电解质复合物膜的渗透性能与其溶胀性能密切相关；复合物膜中壳聚糖和纤维素硫酸钠的配比、相对分子量和pH值对膜的渗透性能和溶胀性能影响显著，以扑热息痛作为模型药物研究了壳聚糖-纤维素硫酸钠聚电解质复合物膜在模拟胃肠液中对药物的渗透性能. 通过调整该复合物膜的配方，可以使该膜分别实现胃、小肠和结肠定位释药的目的.

关键词:

English

Determination of Apparent Drug Permeability Coefficients through Chitosan-Sodium Cellulose Sulfate Polyelectrolyte Complex Films

1.
1 College of Sciences, Nanjing University of Technology, Nanjing 211816, P. R. China;
2 Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, P. R. China;
3 College of Food Science and Light Industry, Nanjing University of Technology, Nanjing 211816, P. R. China
Received Date: 06 October 2013
Available Online: 23 January 2014
Fund Project:
江苏省自然科学基金(BK20131406，BK20130917)

国家自然科学基金(21106064)资助项目

Abstract:

The permeability coefficient is a fundamental parameter for devices exploiting the controlled drugrelease behavior of films composed of chitosan and sodium cellulose sulfate (NaCS). Here, the transport of two model drugs with different solubilities, i.e., paracetamol and 5-aminosalicylic acid (5-ASA), was studied. The results showed that the permeability of the chitosan/NaCS film was closely related to the swelling properties. In addition, both the permeability and swelling properties of the chitosan/NaCS film were significantly influenced by the mass ratio of chitosan to NaCS, the molecular weights (M_w) of chitosan and NaCS, and the pH value. The permeability of paracetamol across the film was also investigated in simulated gastrointestinal solutions in in vitro tests. The results showed that the films have gastro-, intestine-, and colon-targeting drugrelease properties when they are exposed to simulated gastrointestinal fluids in sequence.

Key words:

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

壳聚糖-纤维素硫酸钠聚电解质复合物膜对药物表观渗透系数的测试

English

Determination of Apparent Drug Permeability Coefficients through Chitosan-Sodium Cellulose Sulfate Polyelectrolyte Complex Films

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

壳聚糖-纤维素硫酸钠聚电解质复合物膜对药物表观渗透系数的测试

English

Determination of Apparent Drug Permeability Coefficients through Chitosan-Sodium Cellulose Sulfate Polyelectrolyte Complex Films

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

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