大长径比金纳米棒的合成及其单细胞毒性研究

周海英 周瑞 熊斌 何彦

引用本文: 周海英, 周瑞, 熊斌, 何彦. 大长径比金纳米棒的合成及其单细胞毒性研究[J]. 分析化学, 2012, 40(12): 1807-1815. doi: 10.3724/SP.J.1096.2012.20793 shu
Citation:  ZHOU Hai-Ying, ZHOU Rui, XIONG Bin, HE Yan. Preparation and Cytotoxicity of High-aspect-ratio Gold Nanorods at Single Cell Level[J]. Chinese Journal of Analytical Chemistry, 2012, 40(12): 1807-1815. doi: 10.3724/SP.J.1096.2012.20793 shu

大长径比金纳米棒的合成及其单细胞毒性研究

    通讯作者: 何彦
  • 基金项目:

    本文系国家自然科学基金项目(No.20975036)资助 (No.20975036)

摘要: 利用三步晶种生长法合成长径比约为14的大长径比金纳米棒(GNR),利用巯基十一酸(MUDA)对金纳米棒表面进行了生物适应性修饰,并在宏观水平上研究了修饰前后的金纳米棒在对细胞活性的影响。利用单细胞方法分别考察了修饰后的纳米金棒对细胞贴壁过程、增殖速率、细胞内ROS以及骨架排布的影响。虽然MTT细胞活性结果显示内吞后的金纳米棒对细胞无毒,但单细胞毒性分析方法发现,不同浓度纳米金棒对早期贴壁过程有较小的影响,且内吞的纳米金棒在一定程度上促进了细胞的增殖,而高浓度下纳米金棒引起了细胞内ROS含量的升高,并破坏了细胞内骨架纤维排布。本研究建立了用单细胞行为分析纳米颗粒对细胞毒性的方法,证明了以往仅仅利用MTT等宏观手段分析纳米材料生物适应性是不足的。纳米材料在生物医学领域的进一步应用还应考虑单细胞及分子水平上的毒性效应。

English

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  • 收稿日期:  2012-07-26
  • 网络出版日期:  2012-09-19
通讯作者: 陈斌, bchen63@163.com
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