原子转移自由基聚合在生物传感中的应用

引用本文: 李颖, 吴亚锋, 袁亮, 刘松琴. 原子转移自由基聚合在生物传感中的应用[J]. 分析化学, 2012, 40(12): 1797-1802. doi: 10.3724/SP.J.1096.2012.20531 shu

Citation: LI Ying, WU Ya-Feng, YUAN Liang, LIU Song-Qin. Application of Atom Transfer Radical Polymerization in Biosensing[J]. Chinese Journal of Analytical Chemistry, 2012, 40(12): 1797-1802. doi: 10.3724/SP.J.1096.2012.20531 shu

原子转移自由基聚合在生物传感中的应用

通讯作者: 刘松琴

基金项目:
本文系国家自然科学基金资助项目(No.20875013) (No.20875013)

摘要: 原子转移自由基聚合(ATRP)是一种新颖的信号放大方法。在聚合过程中,成百上千个单体分子聚集形成长链聚合物,聚合物的侧链可以修饰丰富的功能基团,可与电化学或光学活性物质发生键合反应,从而显著增加单元生物分子识别反应信号分子的负载量,提高了检测灵敏度,实现了生物分子检测的信号放大。本文综述了ATRP的反应机理及其近年来在生物传感中的应用,并展望了其发展前景。

关键词:

English

Application of Atom Transfer Radical Polymerization in Biosensing

1.
School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, China

Corresponding author: 刘松琴

Received Date: 23 May 2012
Fund Project:
本文系国家自然科学基金资助项目(No.20875013)

Abstract: Atom transfer radical polymerization (ATRP) is a new class of signal amplification method. The polymer growth results in local accumulation of monomers to form long-chain polymers. The growth of long chain polymeric materials provides excess active groups for electroactive or photoactive molecules coupling, which in turn significantly increases the loading of signal molecules and enhanced detection sensitivity. This review introduced the mechanism of ATRP, summarized the recent application of ATRP in biosensing. Particularly, future study and prospect were envisioned.

Key words:

1. [1]
  1 Matyjaszewski K, Xia J H. Chem. Rev., 2001, 101(9): 2921-29901 Matyjaszewski K, Xia J H. Chem. Rev., 2001, 101(9): 2921-2990
2. [2]
  2 Srivastava A, Mishra V, Singh P, Kumar R. J. Appl. Polym. Sci., 2012, 126(2): 395-4072 Srivastava A, Mishra V, Singh P, Kumar R. J. Appl. Polym. Sci., 2012, 126(2): 395-407
3. [3]
  3 Bunha A K, Mangadlao J, Felipe M J, Pangilinan K, Advincula R. Macromol. Rapid. Comm., 2012, 33(14): 1214-12193 Bunha A K, Mangadlao J, Felipe M J, Pangilinan K, Advincula R. Macromol. Rapid. Comm., 2012, 33(14): 1214-1219
4. [4]
  4 Gilroy J B, Lunn D J, Patra S K, Winnik M A, Manners I. Macromolecules, 2012, 45(14): 5906-58154 Gilroy J B, Lunn D J, Patra S K, Winnik M A, Manners I. Macromolecules, 2012, 45(14): 5906-5815
5. [5]
  5 Yao Z L, Tam K C. Polymer, 2012, 53(16): 3446-34535 Yao Z L, Tam K C. Polymer, 2012, 53(16): 3446-3453
6. [6]
  6 Nguyen A T, Baggerman J, Paulusse J M J, Zuilhof H, van Rijn C J M. Langmuir, 2012, 28(1): 604-6106 Nguyen A T, Baggerman J, Paulusse J M J, Zuilhof H, van Rijn C J M. Langmuir, 2012, 28(1): 604-610
7. [7]
  7 Nguyen A T, Baggerman J, Paulusse J M J, van Rijn C J M, Zuilhof H. Langmuir, 2011, 27(6): 2587-25947 Nguyen A T, Baggerman J, Paulusse J M J, van Rijn C J M, Zuilhof H. Langmuir, 2011, 27(6): 2587-2594
8. [8]
  8 Zhang Z B, Yuan S J, Zhu X L, Neoh K G, Kang E T. Biosens. Bioelectron., 2010, 25(5): 1102-11088 Zhang Z B, Yuan S J, Zhu X L, Neoh K G, Kang E T. Biosens. Bioelectron., 2010, 25(5): 1102-1108
9. [9]
  9 Qian H, He L.Anal. Chem., 2009, 81(23): 9824-98279 Qian H, He L.Anal. Chem., 2009, 81(23): 9824-9827
10. [10]
  10 Wong A K Y, Krull U J. Anal. Chim. Acta, 2009, 639(1-2): 1-1210 Wong A K Y, Krull U J. Anal. Chim. Acta, 2009, 639(1-2): 1-12
11. [11]
  11 Lou X H, Lewis M S, He L. Anal. Chem., 2005, 77(15): 4698-470511 Lou X H, Lewis M S, He L. Anal. Chem., 2005, 77(15): 4698-4705
12. [12]
  12 Lou X H, He L. Langmuir, 2006, 22(6): 2640-264612 Lou X H, He L. Langmuir, 2006, 22(6): 2640-2646
13. [13]
  13 Wang J S, Matyjaszewski K. J. Am. Chem. Soc., 1995, 117(20): 5614-561513 Wang J S, Matyjaszewski K. J. Am. Chem. Soc., 1995, 117(20): 5614-5615
14. [14]
  14 Matyjaszewski K. Curr. Org. Chem., 2002, 6(2): 67-8214 Matyjaszewski K. Curr. Org. Chem., 2002, 6(2): 67-82
15. [15]
  15 Matyjaszewski K, Ziegler M J, Arehart S V, Pakula T. J. Phys. Org. Chem., 2000, 13(12): 775-78615 Matyjaszewski K, Ziegler M J, Arehart S V, Pakula T. J. Phys. Org. Chem., 2000, 13(12): 775-786
16. [16]
  16 Lutz J F, Neugebauer D, Matyjaszewski K. J. Am. Chem. Soc., 2003, 125(23): 6986-699316 Lutz J F, Neugebauer D, Matyjaszewski K. J. Am. Chem. Soc., 2003, 125(23): 6986-6993
17. [17]
  17 Lutz J F, Kirci B, Matyjaszewski K. Macromolecules, 2003, 36(9): 3136-314517 Lutz J F, Kirci B, Matyjaszewski K. Macromolecules, 2003, 36(9): 3136-3145
18. [18]
  18 Hong S C, Lutz J F, Inoue Y, Strissel C, Nuyken O, Matyjaszewski K. Macromolecules, 2003, 36(4): 1075-108218 Hong S C, Lutz J F, Inoue Y, Strissel C, Nuyken O, Matyjaszewski K. Macromolecules, 2003, 36(4): 1075-1082
19. [19]
  19 Hadjichristidis N, Pitsikalis M, Pispas S, Iatrou H. Chem. Rev., 2001, 101(12): 3747-379219 Hadjichristidis N, Pitsikalis M, Pispas S, Iatrou H. Chem. Rev., 2001, 101(12): 3747-3792
20. [20]
  20 Hong S C, Neugebauer D, Inoue Y, Lutz J F, Matyjaszewski K. Macromolecules, 2003, 36(1): 27-3520 Hong S C, Neugebauer D, Inoue Y, Lutz J F, Matyjaszewski K. Macromolecules, 2003, 36(1): 27-35
21. [21]
  21 Pitsikalis M, Pispas S, Mays J W, Hadjichristidis N. Blockcopolymers Polyelectrolytes Biodegradation, 1998, 135: 1-13721 Pitsikalis M, Pispas S, Mays J W, Hadjichristidis N. Blockcopolymers Polyelectrolytes Biodegradation, 1998, 135: 1-137
22. [22]
  22 Borner H G, Duran D, Matyjaszewski K, da Silva M, Sheiko S S. Macromolecules, 2002, 35(9): 3387-339422 Borner H G, Duran D, Matyjaszewski K, da Silva M, Sheiko S S. Macromolecules, 2002, 35(9): 3387-3394
23. [23]
  23 Gaynor S G, Edelman S, Matyjaszewski K. Macromolecules, 1996, 29(3): 1079-108123 Gaynor S G, Edelman S, Matyjaszewski K. Macromolecules, 1996, 29(3): 1079-1081
24. [24]
  24 Matyjaszewski K, Gaynor S G, Kulfan A, Muller A H E. Macromolecules, 1997, 30(17): 5192-519424 Matyjaszewski K, Gaynor S G, Kulfan A, Muller A H E. Macromolecules, 1997, 30(17): 5192-5194
25. [25]
  25 Matyjaszewski K, Gaynor S G, Muller A H E. Macromolecules, 1997, 30(23): 7034-704125 Matyjaszewski K, Gaynor S G, Muller A H E. Macromolecules, 1997, 30(23): 7034-7041
26. [26]
  26 Matyjaszewski K, Gaynor S G. Macromolecules, 1997, 30(23): 7042-704926 Matyjaszewski K, Gaynor S G. Macromolecules, 1997, 30(23): 7042-7049
27. [27]
  27 Matyjaszewski K, Pyun J, Gaynor S G. Macromol. Rapid. Comm., 1998, 19(12): 665-67027 Matyjaszewski K, Pyun J, Gaynor S G. Macromol. Rapid. Comm., 1998, 19(12): 665-670
28. [28]
  28 Matyjaszewski K. Polym. Int., 2003, 52(10): 1559-156528 Matyjaszewski K. Polym. Int., 2003, 52(10): 1559-1565
29. [29]
  29 Beers K L, Gaynor S G, Matyjaszewski K, Sheiko S S, Moller M. Macromolecules, 1998, 31(26): 9413-941529 Beers K L, Gaynor S G, Matyjaszewski K, Sheiko S S, Moller M. Macromolecules, 1998, 31(26): 9413-9415
30. [30]
  30 Luzinov I, Minko S, Tsukruk V V. Prog. Polym. Sci., 2004, 29(7): 635-69830 Luzinov I, Minko S, Tsukruk V V. Prog. Polym. Sci., 2004, 29(7): 635-698
31. [31]
  31 Pyun J, Kowalewski T, Matyjaszewski K. Macromol. Rapid. Comm., 2003, 24(18): 1043-105931 Pyun J, Kowalewski T, Matyjaszewski K. Macromol. Rapid. Comm., 2003, 24(18): 1043-1059
32. [32]
  32 Liu Y, Cheng Q. Anal. Chem., 2012, 84(7): 3179-318632 Liu Y, Cheng Q. Anal. Chem., 2012, 84(7): 3179-3186
33. [33]
  33 Liu Y, Dong Y, Jauw J, Linman M J, Cheng Q. Anal. Chem., 2010, 82(9): 3679-368533 Liu Y, Dong Y, Jauw J, Linman M J, Cheng Q. Anal. Chem., 2010, 82(9): 3679-3685
34. [34]
  34 Qian H, He, L. Sensors and Actuators B, 2010, 150(2): 594-60034 Qian H, He, L. Sensors and Actuators B, 2010, 150(2): 594-600
35. [35]
  35 He P, Zheng W M,Tucker E Z, Gorman C B, He L. Anal. Chem., 2008, 80(10): 3633-363935 He P, Zheng W M,Tucker E Z, Gorman C B, He L. Anal. Chem., 2008, 80(10): 3633-3639
36. [36]
  36 Wang J S, Matyjaszewski K. J. Am. Chem. Soc., 1995, 117(20): 5614-561536 Wang J S, Matyjaszewski K. J. Am. Chem. Soc., 1995, 117(20): 5614-5615
37. [37]
  37 Chen J K, Li J Y. Sensors and Actuators B, 2010, 150(1): 314-32037 Chen J K, Li J Y. Sensors and Actuators B, 2010, 150(1): 314-320
38. [38]
  38 Lou X H, He L. Langmuir, 2006, 22(6): 2640-264638 Lou X H, He L. Langmuir, 2006, 22(6): 2640-2646
39. [39]
  39 Zheng W M, He L. Anal. Bioanal. Chem., 2010, 397(6): 2261-227039 Zheng W M, He L. Anal. Bioanal. Chem., 2010, 397(6): 2261-2270
40. [40]
  40 Wu Y F, Liu S Q, He L. Anal. Chem., 2009, 81(16): 7015-702140 Wu Y F, Liu S Q, He L. Anal. Chem., 2009, 81(16): 7015-7021
41. [41]
  41 Wu Y F, Liu S Q, He L. Analyst, 2011, 136(12): 2558-256341 Wu Y F, Liu S Q, He L. Analyst, 2011, 136(12): 2558-2563
42. [42]
  42 Wu Y F, Liu S Q, He L. Biosens. Bioelectron., 2010, 26(3): 970-97542 Wu Y F, Liu S Q, He L. Biosens. Bioelectron., 2010, 26(3): 970-975
43. [43]
  43 Wu Y F, Shi H Y, Yuan L A, Liu S Q. Chem. Commun., 2010, 46(41): 7763-776543 Wu Y F, Shi H Y, Yuan L A, Liu S Q. Chem. Commun., 2010, 46(41): 7763-7765
44. [44]
  44 Yuan LA, Wu Y F, Shi H Y, Liu S Q. Chem. Eur. J., 2011, 17(3): 976-98344 Yuan LA, Wu Y F, Shi H Y, Liu S Q. Chem. Eur. J., 2011, 17(3): 976-983
45. [45]
  45 Shi H Y,Yuan L A, Wu Y F, Liu S Q. Biosens. Bioelectron., 2011, 26(9): 3788-379345 Shi H Y,Yuan L A, Wu Y F, Liu S Q. Biosens. Bioelectron., 2011, 26(9): 3788-3793

扫一扫看文章

计量

PDF下载量: 0
文章访问数: 466
HTML全文浏览量: 34

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

原子转移自由基聚合在生物传感中的应用

通讯作者: 刘松琴

English

Application of Atom Transfer Radical Polymerization in Biosensing

Corresponding author: 刘松琴

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

原子转移自由基聚合在生物传感中的应用

通讯作者: 刘松琴

English

Application of Atom Transfer Radical Polymerization in Biosensing

Corresponding author: 刘松琴

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs