时间分辨-后化学发光法同时测定阿米卡星和氢氯噻嗪

引用本文: 郭伟, 闫瑞芳, 袁建梅, 章竹君, 苗江欢. 时间分辨-后化学发光法同时测定阿米卡星和氢氯噻嗪[J]. 分析化学, 2012, 40(12): 1907-1912. doi: 10.3724/SP.J.1096.2012.20255 shu

Citation: GUO Wei, YAN Rui-Fang, YUAN Jian-Mei, ZHANG Zhu-Jun, MIAO Jiang-Huan. Time-resolved Post-Chemiluminescence Analysis for Simultaneous Determination of Amikacin and Hydrochlorothiazide[J]. Chinese Journal of Analytical Chemistry, 2012, 40(12): 1907-1912. doi: 10.3724/SP.J.1096.2012.20255 shu

时间分辨-后化学发光法同时测定阿米卡星和氢氯噻嗪

郭伟 ^{1,
,} ,
闫瑞芳 ^1,2, ,
袁建梅 ^1, ,
章竹君 ^3, ,
苗江欢 ^2,

通讯作者: 郭伟

基金项目:
本文系国家自然科学基金资助项目(No.30470886) (No.30470886)

新乡医学院高学历人才资助项目

摘要: 根据阿米卡星、氢氯噻嗪在过氧化单硫酸盐(PMS)-鲁米诺(Luminol)体系中的化学发光反应的动力学性质有着明显的差异性,建立了同时测定阿米卡星和氢氯噻嗪新的时间分辨后化学发光的方法。在PMS-鲁米诺体系中,氢氯噻嗪化学发光反应较快,1 s达到最大值,峰尖锐;而阿米卡星化学发光反应较慢,37.9 s后达到最大值,峰平缓,且其动力学曲线呈现出随时间分开的两个独立的发光峰,互不干扰。结果表明;氢氯噻嗪和阿米卡星的线性范围分别为8.0×10^-5-4.0×10^-3 g/L和8.0×10^-4-4.0×10^-2 g/L;11次平行测定4.0×10^-4 g/L氢氯噻嗪溶液和4.0×10^-3 g/L阿米卡星溶液的化学发光强度相对标准偏差分别为2.4%和3.7%。本方法测定氢氯噻嗪和阿米卡星的检出限分别为2.0×10^-5和2.0×10^-4 g/L。

关键词:

English

Time-resolved Post-Chemiluminescence Analysis for Simultaneous Determination of Amikacin and Hydrochlorothiazide

1.
¹ Department of Chemistry, Xinxiang Medical University, Xinxiang 453003, China;

Corresponding author: 郭伟

Received Date: 13 March 2012
Fund Project:
本文系国家自然科学基金资助项目(No.30470886)

新乡医学院高学历人才资助项目

Abstract: Based on the differential chemiluminescent rate of amikacin (AMK) and hydrochlorothiazide (HCT) in the system of Luminol-peroxymonosulfate (PMS), a novel time-resolved post-chemiluminescence method was established for the simultaneous determination of AMK and HCT. The HCT system gives the highest chemiluminescence intensity at 1 s, whereas the AMK system gives its most intense chemiluminescence emission at 39.7 s. The kinetic curve showed two separate chemiluminescence peaks at different time without disturbing each other. Under the optimum conditions described above, the analytical performance was obtained. The linear response for the determination of HCT and AMK was in the range from 8.0×10^-5 to 4.0×10^-3 g/L and from 8.0×10^-4 to 4.0×10^-2 g/L. The relative standard diviation of AMK (4.0×10^-3 g/L) and HCT (4.0×10^-4 g/L) are 3.7% and 2.4% (n=11), and the detection limit (3) of AMK and HCT are 2.0×10^-4 g/L and 2.0×10^-5 g/L, respectively.

Key words:

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

时间分辨-后化学发光法同时测定阿米卡星和氢氯噻嗪

通讯作者: 郭伟

English

Time-resolved Post-Chemiluminescence Analysis for Simultaneous Determination of Amikacin and Hydrochlorothiazide

Corresponding author: 郭伟

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

时间分辨-后化学发光法同时测定阿米卡星和氢氯噻嗪

通讯作者: 郭伟

English

Time-resolved Post-Chemiluminescence Analysis for Simultaneous Determination of Amikacin and Hydrochlorothiazide

Corresponding author: 郭伟

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs