石墨烯/L-胱氨酸复合膜修饰玻碳电极测定盐酸异丙肾上腺素的研究

引用本文: 甘静妮, 蔡卓, 何晓良, 邱霞琳, 岳伟超. 石墨烯/L-胱氨酸复合膜修饰玻碳电极测定盐酸异丙肾上腺素的研究[J]. 分析化学, 2012, 40(12): 1877-1882. doi: 10.3724/SP.J.1096.2012.11429 shu

Citation: GAN Jing-Ni, CAI Zhuo, HE Xiao-Liang, QIU Xia-Lin, YUE Wei-Chao. Determination of Isoprenaline Hydrochloride Using Graphene-L-Cystine Composite Film Modified Glassy Carbon Electrode[J]. Chinese Journal of Analytical Chemistry, 2012, 40(12): 1877-1882. doi: 10.3724/SP.J.1096.2012.11429 shu

石墨烯/L-胱氨酸复合膜修饰玻碳电极测定盐酸异丙肾上腺素的研究

通讯作者: 蔡卓

基金项目:
本文系广西自然科学基金(No.2010GXNSFA013001)资助项目 (No.2010GXNSFA013001)

摘要: 研制了石墨烯与L-胱氨酸复合膜化学修饰电极(GR-L-CysS/GCE),并研究了盐酸异丙肾上腺素在修饰电极上的电化学行为和测定方法。结果表明,在0.2 mol/L Na₂HPO₄-柠檬酸(pH 7.4)溶液中,GR-L-CysS/GCE对盐酸异丙肾上腺素的电化学氧化具有明显的催化增敏作用,氧化峰电流相对于在裸玻碳电极上增加了13倍。在优化实验条件下,定量测定的线性范围为4.0×10^-6-1.6×10^-4 mol/L,r为0.9977,方法检出限(S/N=3)为8.4×10^-7 mol/L。探讨了盐酸异丙肾上腺素在GR-L-CysS/GCE上的电催化过程和反应机理,测得在本体系中参与反应的电子转移数和质子数均为1,电子转移系数为0.4635。对样品进行测定及加标回收实验,回收率在94.9%-102.9%之间。

关键词:

English

Determination of Isoprenaline Hydrochloride Using Graphene-L-Cystine Composite Film Modified Glassy Carbon Electrode

1.
College of Chemistry and Chemical Engineering, University of Guangxi, Nanning 530004, China

Corresponding author: 蔡卓

Received Date: 11 April 2012
Fund Project:
本文系广西自然科学基金(No.2010GXNSFA013001)资助项目

Abstract: A graphene-L-cystine modified glassy carbon electrode (GR-L-CysS/GCE) has been prepared. The electrochemical behavior of isoprenaline hydrochloride at the modified electrode has been studied. In 0.2 mol/L Na₂HPO₄-citric acid (pH 7.4) buffer, GR-L-CysS/GCE exhibited excellent catalytic and enhancement effect on the electrochemical oxidation of isoprenaline hydrochloride, and the oxidation peak current increased ca.13 times compared with that at bare GCE. The measurement parameters were optimized. Under the optimal conditions, isoprenaline hydrochloride concentration was linear with peak current in the range of 4.0×10^-6-1.6×10^-4 mol/L (R=0.9977), and the detection limit was 8.4×10^-7 mol/L(S/N=3). The mechanism investigation showed that the reaction of isoprenaline hydrochloride at the modified electrode was a process with one-proton and one-electron transfer, and the coefficient of electron transfer α is 0.4635. This method was successfully used in the determination of isoprenaline hydrochloride in injection with the recovery between 94.9%-102.9%.

Key words:

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

石墨烯/L-胱氨酸复合膜修饰玻碳电极测定盐酸异丙肾上腺素的研究

通讯作者: 蔡卓

English

Determination of Isoprenaline Hydrochloride Using Graphene-L-Cystine Composite Film Modified Glassy Carbon Electrode

Corresponding author: 蔡卓

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

石墨烯/L-胱氨酸复合膜修饰玻碳电极测定盐酸异丙肾上腺素的研究

通讯作者: 蔡卓

English

Determination of Isoprenaline Hydrochloride Using Graphene-L-Cystine Composite Film Modified Glassy Carbon Electrode

Corresponding author: 蔡卓

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

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