引用本文:
白灵, 肖鸽, 卓广澜. CBS催化硼烷胺配合物不对称还原法制备(S)-3-氯-1-苯基-1-丙醇[J]. 应用化学,
2012, 29(9): 1087-1089.
doi:
10.3724/SP.J.1095.2012.00451
Citation: BAI Ling, XIAO Ge, ZHUO Guanglan. Asymmetric Synthesis of(S)-3-Chloro-1-phenyl-1-propanol Using Borane Amine Complex-CBS as Catalyst[J]. Chinese Journal of Applied Chemistry, 2012, 29(9): 1087-1089. doi: 10.3724/SP.J.1095.2012.00451
Citation: BAI Ling, XIAO Ge, ZHUO Guanglan. Asymmetric Synthesis of(S)-3-Chloro-1-phenyl-1-propanol Using Borane Amine Complex-CBS as Catalyst[J]. Chinese Journal of Applied Chemistry, 2012, 29(9): 1087-1089. doi: 10.3724/SP.J.1095.2012.00451
CBS催化硼烷胺配合物不对称还原法制备(S)-3-氯-1-苯基-1-丙醇
English
Asymmetric Synthesis of(S)-3-Chloro-1-phenyl-1-propanol Using Borane Amine Complex-CBS as Catalyst
Abstract:
(S)-3-Chloro-1-phenyl-1-propanol was synthesized asymmetrically by using catalysts(R)-α,α-diphenyl-2-pyrrolidinemethanol,(1R,2S)-2-amino-1,2-diphenylethanol and(1R,2R)-1-amino-2-indanol with amine borane complexes,with a yield of 88.3%~93.8%,ee% 81.6~87.7.These amine borane complexes are more stable and safe than the borane-tetrahydrofuran complex and borane-methyl sulfide complex.
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Key words:
- borane amine complex
- / CBS catalyst
- / (S)-chlorophenylpropanol
- / fluoxetine
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