引用本文:
滕汉兵. Nω-羟基-nor-L-精氨酸的合成[J]. 应用化学,
2010, 27(9): 1111-1113.
doi:
10.3724/SP.J.1095.2010.90811
Citation: TENG Han-Bing. Synthesis of Nω-Hydroxy-nor-L-arginine[J]. Chinese Journal of Applied Chemistry, 2010, 27(9): 1111-1113. doi: 10.3724/SP.J.1095.2010.90811
Citation: TENG Han-Bing. Synthesis of Nω-Hydroxy-nor-L-arginine[J]. Chinese Journal of Applied Chemistry, 2010, 27(9): 1111-1113. doi: 10.3724/SP.J.1095.2010.90811
Nω-羟基-nor-L-精氨酸的合成
English
Synthesis of Nω-Hydroxy-nor-L-arginine
Abstract:
The arginase inhibitor Nω-hydroxy-nor-L-arginine dihydrochloride was successfully synthesized from Nα-Boc-L-glutamine precursor.The expensive reagent was not required in the synthetic process and a seven-step reaction was reduced to a three-step one.Not only was the separation procedure simplified,but also the total yield was increased from 21% to 37%.
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Key words:
- arginase inhibitor
- / amino-protecting
- / synthesis
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