基于代谢组学的新疆一枝蒿生长关键成分研究

引用本文: 王纪阳, 周帜, 谢冰, 崔星云, 拉毛卓玛, 王中华, 再帕尔·阿不力孜. 基于代谢组学的新疆一枝蒿生长关键成分研究[J]. 分析化学, 2023, 51(3): 390-396. doi: 10.19756/j.issn.0253-3820.221436 shu

Citation: WANG Ji-Yang, ZHOU Zhi, XIE Bing, CUI Xing-Yun, LAMAO Zhuo-Ma, WANG Zhong-Hua, ABLIZ Zeper. Study on Key Growth Components of Artemisia rupestris L. Based on Metabolomics[J]. Chinese Journal of Analytical Chemistry, 2023, 51(3): 390-396. doi: 10.19756/j.issn.0253-3820.221436 shu

基于代谢组学的新疆一枝蒿生长关键成分研究

1.
中央民族大学质谱成像与代谢组学国家民委重点实验室, 北京 100081;
2.
中央民族大学民族医药教育部重点实验室, 北京 100081;
3.
中央民族大学药学院, 北京 100081

通讯作者: 周帜,E-mail:zhouzhi@muc.edu.cn

基金项目:
国家自然科学基金项目(No.2167050718)资助。

摘要: 新疆一枝蒿是维吾尔医学常用药用植物,由于其独特的生态特性,自然繁殖极为困难,尤其近年来野生资源已经逐渐匮乏,因而开展其引种、驯化和人工栽培等研究是实现资源可持续利用最有效的手段。药用植物的物质基础通常有生长发育时期的特异性,深入探讨新疆一枝蒿生长发育过程与关键成分代谢模式的相关性有助于揭示其生理与代谢适应机制。本研究采用基于液相色谱-质谱联用技术的植物代谢组学研究方法,分析了采自新疆阿勒泰富蕴和哈密两个地区处于幼苗期、发育期和盛花期的新疆一枝蒿全草样本,通过整合两地区数据并结合动态规律分析,筛选出24种与该植物生长发育密切相关的代谢物。进一步,基于这24种生长关键成分,构建了贝叶斯判别分析模型,可用于未知样本的采收时期判别。本研究为新疆一枝蒿的质量控制和合理利用提供了参考信息,也为其它药用植物的相关研究提供了研究思路。

关键词:

English

Study on Key Growth Components of Artemisia rupestris L. Based on Metabolomics

1.
Key Laboratory of Mass Spectrometry Imaging and Metabolomics of State Ethnic Affairs Commision, Minzu University of China, Beijing 100081, China;
2.
Key Laboratory of Ethnomedicine of Ministry of Education, Minzu University of China, Beijing 100081, China;
3.
College of Pharmacy, Minzu University of China, Beijing 100081, China

Corresponding author: ZHOU Zhi, zhouzhi@muc.edu.cn

Received Date: 30 August 2022
Revised Date: 03 November 2022
Fund Project:
Supported by the National Natural Science Foundation of China (No. 2167050718).

Abstract: Artemisia rupestris L. (A. rupestris) is a kind of commonly used medicinal plant in Uygur medicine. Due to its unique ecological characteristics, it is extremely difficult to reproduce naturally, and wild resources have been scarce in recent years. Therefore, conducting introduction, domestication and artificial cultivation researches are the most effective means to realize the sustainable utilization of resources. The material basis of medicinal plants is usually specific for the period of growth and development. Thus, an in-depth study of the correlation between the growth period and the metabolic patterns of key components will help to reveal the physiological and metabolic adaptation mechanism of A. rupestris. In this study, plant metabolomics strategy based on liquid chromatography-mass spectrometry technique was applied to analyze A. rupestris samples of different growth periods, including seedling stage, development phase, and full-bloom stage, which were collected from Xinjiang Altay Fuyun and Hami regions. Twenty-four metabolites that were closely related to the plant growth and development were screened by integrated analysis of the two regions data and dynamic regulation description. Furthermore, a Bayesian discriminant analysis model based on 24 key growth components was constructed, which could be used to discriminate the harvesting period of unknown samples. This study provided new reference information for quality control and rational utilization of A. rupestris., and also provided research ideas for other medicinal plants.

Key words:

Artemisia rupestris L.
/ Metabolomics
/ Liquid chromatography-mass spectrometry technique
/ Harvest period
/ Key growth component

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

基于代谢组学的新疆一枝蒿生长关键成分研究

通讯作者: 周帜,E-mail:zhouzhi@muc.edu.cn

English

Study on Key Growth Components of Artemisia rupestris L. Based on Metabolomics

Corresponding author: ZHOU Zhi, zhouzhi@muc.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

基于代谢组学的新疆一枝蒿生长关键成分研究

通讯作者: 周帜,E-mail:zhouzhi@muc.edu.cn

English

Study on Key Growth Components of Artemisia rupestris L. Based on Metabolomics

Corresponding author: ZHOU Zhi, zhouzhi@muc.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs