5,6-二甲基-2,3-吡嗪二甲酰胺-铜配合物的合成及其抗菌活性

文丽君 王英 李海霞 李娟

引用本文: 文丽君, 王英, 李海霞, 李娟. 5,6-二甲基-2,3-吡嗪二甲酰胺-铜配合物的合成及其抗菌活性[J]. 应用化学, 2016, 33(9): 1056-1060. doi: 10.11944/j.issn.1000-0518.2016.09.150302 shu
Citation:  WEN Lijun, WANG Ying, LI Haixia, LI Juan. Synthesis and Antibacterial Activity of 5,6-Dimethyl-2,3-pyrazinedimethylformamide-Cu[J]. Chinese Journal of Applied Chemistry, 2016, 33(9): 1056-1060. doi: 10.11944/j.issn.1000-0518.2016.09.150302 shu

5,6-二甲基-2,3-吡嗪二甲酰胺-铜配合物的合成及其抗菌活性

    通讯作者: 李海霞,副教授;Tel:0898-66972095;E-mail:782430794@qq.com;研究方向:配合物药物
  • 基金项目:

    海南医学院科研培育基金项目(HY2013-23);海南省自然科学基金项目(20152040) 

摘要: 以2,3-二甲基-5,6-二氰基吡嗪为原料,稀碱条件下不完全氧化得到配体5,6-二甲基-2,3-吡嗪二甲酰胺,再与醋酸铜在弱碱条件下合成5,6-二甲基-2,3-吡嗪二甲酰胺-铜配合物;采用牛津杯法预试验及试管二倍稀释法研究配体5,6-二甲基-2,3-吡嗪二甲酰胺及其配合物的抗菌活性。对合成的配合物通过紫外光谱、红外光谱、差热-热重分析进行确证表征。该配合物表现出较好的抑菌和杀菌作用,对大肠埃希菌的MIC和MBC均为50 mg/L,对金黄色葡萄球菌的MIC和MBC均为25 mg/L,而配体没有明显的抑菌杀菌作用,从而为临床疾病的治疗和食品添加剂的研发提供参考。

English

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  • 收稿日期:  2015-08-19
  • 网络出版日期:  2016-01-05
通讯作者: 陈斌, bchen63@163.com
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