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2-吡咯类酰腙的合成、晶体结构及与小牛胸腺DNA的相互作用

毛新洁 ,  刘向荣 ,  赵顺省 ,  杨再文 ,  闫森

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引用本文: 毛新洁, 刘向荣, 赵顺省, 杨再文, 闫森. 2-吡咯类酰腙的合成、晶体结构及与小牛胸腺DNA的相互作用[J]. 应用化学, 2016, 33(8): 923-931. doi: 10.11944/j.issn.1000-0518.2016.08.150398 shu
Citation:  MAO Xinjie, LIU Xiangrong, ZHAO Shunsheng, YANG Zaiwen, YAN Sen. Synthesis, Crystal Structures and Calf Thymus DNA Binding of Acylhydrazone Bearing Pyrrole Ring[J]. Chinese Journal of Applied Chemistry, 2016, 33(8): 923-931. doi: 10.11944/j.issn.1000-0518.2016.08.150398 shu

2-吡咯类酰腙的合成、晶体结构及与小牛胸腺DNA的相互作用

  • 1.

    西安科技大学化学与化工学院 西安 710054

    • 通讯作者: 刘向荣,教授; Tel/Fax:029-85583183; E-mail:liuxiangrongxk@163.com; 研究方向:金属有机化学
  • 基金项目:

    国家自然科学基金（21073139,21301139,21103135） 

摘要: 以2-吡咯甲酰肼与2,4-二羟基苯甲醛和2-羟基-3-甲氧基苯甲醛经缩合反应合成2,4-二羟基苯甲醛-2-吡咯甲酰腙C12H11N3O3（Ⅰ）和2-羟基-3-甲氧基苯甲醛-2-吡咯甲酰腙C13H15N3O4（Ⅱ），并利用红外光谱、元素分析、1H NMR、X射线单晶衍射和热重分析进行表征，结果表明晶体Ⅰ属单斜晶系，空间群为P21/c，Z=4，晶胞参数为a=1.2586（4）nm，b=0.8050（3）nm，c=1.1914（4）nm；晶体Ⅱ为正交晶系，空间群为P212121，Z=4，晶胞参数为a=0.4756（2）nm，b=1.2491（6）nm，c=2.2145（11）nm。热重结果显示，化合物Ⅰ和Ⅱ最大热分解峰分别出现在267.59和284.79 ℃，表观活化能分别为176.6和122.9 kJ/mol，表明化合物Ⅰ和Ⅱ具有较高的热稳定性。利用粘度实验和微量热实验研究了化合物Ⅰ和Ⅱ与CT-DNA的相互作用，均显示两种化合物均与CT-DNA发生了插入作用，且相互作用过程放热，焓变值分别为ΔH（Ⅰ）=4.67 kJ/mol和ΔH（Ⅱ）=4.40 kJ/mol。

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  • 收稿日期:  2015-11-13
  • 网络出版日期:  2016-02-24
通讯作者: 陈斌, bchen63@163.com
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