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藤黄酸氰基衍生物的合成及抗肿瘤活性

陈美君 ,  黎金海 ,  张志佳 ,  廖思燕 ,  黄雁 ,  谭茵

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引用本文: 陈美君, 黎金海, 张志佳, 廖思燕, 黄雁, 谭茵. 藤黄酸氰基衍生物的合成及抗肿瘤活性[J]. 应用化学, 2016, 33(8): 905-912. doi: 10.11944/j.issn.1000-0518.2016.08.150397 shu
Citation:  CHEN Meijun, LI Jinhai, ZHANG Zhijia, LIAO Siyan, HUANG Yan, TAN Yin. Synthesis and Anti-tumor Evaluation of Nitrile-Containing Gambogic Acid Derivatives[J]. Chinese Journal of Applied Chemistry, 2016, 33(8): 905-912. doi: 10.11944/j.issn.1000-0518.2016.08.150397 shu

藤黄酸氰基衍生物的合成及抗肿瘤活性

  • 1.

    广州医科大学药学院 广州 511436

    • 通讯作者: 黄雁,教授; Tel:020-37103254; E-mail:drhuangyan@163.com; 研究方向:药物化学通讯联系人:谭茵,高级实验师; Tel:020-37103235; E-mail:shwhxsy@gzhmc.edu.cn; 研究方向:药理活性研究; 黄雁,教授; Tel:020-37103254; E-mail:drhuangyan@163.com; 研究方向:药物化学通讯联系人:谭茵,高级实验师; Tel:020-37103235; E-mail:shwhxsy@gzhmc.edu.cn; 研究方向:药理活性研究
  • 基金项目:

    广东省科技计划资助项目（2013B031800021） 

摘要: 以藤黄酸为原料，经过酯化反应或酰胺化反应，在C-30位的羧基上引入不同的烷氰基或芳香氰基，设计合成了7个藤黄酸氰基衍生物，其中6个为新化合物，其结构经MS和1H NMR确证。采用四氮唑蓝（MTT）法测试了合成化合物对肝癌细胞（HepG2）、结肠腺癌细胞（RKO）和卵巢腺癌细胞（OVCAR-3）的体外抗肿瘤活性，结果表明，所合成的化合物均具有一定的抗肿瘤活性,其中化合物4和6的抗肿瘤活性明显优于阳性对照物藤黄酸。

English

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  • 收稿日期:  2015-11-10
  • 网络出版日期:  2016-02-29
通讯作者: 陈斌, bchen63@163.com
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