新型含巴比妥酸的芳香酰腙类化合物的合成、晶体结构及抑菌活性

冯洋 李传碧 赵丽婷 李家琪 魏亚男

引用本文: 冯洋, 李传碧, 赵丽婷, 李家琪, 魏亚男. 新型含巴比妥酸的芳香酰腙类化合物的合成、晶体结构及抑菌活性[J]. 应用化学, 2016, 33(8): 913-922. doi: 10.11944/j.issn.1000-0518.2016.08.150386 shu
Citation:  FENG Yang, LI Chuanbi, ZHAO Liting, LI Jiaqi, WEI Ya'nan. Synthesis, Crystal Structure and Antimicrobial Activities of Novel Aroylhydrazones Containing Barbituric Acid Moiety[J]. Chinese Journal of Applied Chemistry, 2016, 33(8): 913-922. doi: 10.11944/j.issn.1000-0518.2016.08.150386 shu

新型含巴比妥酸的芳香酰腙类化合物的合成、晶体结构及抑菌活性

    通讯作者: 李传碧,教授; Tel:0431-81765057; Fax:0431-81765055; E-mail:15844408085@163.com; 研究方向:有机合成
  • 基金项目:

    吉林省科技厅基金资助项目(20140204080) 

摘要: 在微波辅助下,1,3-二甲基-5-醛基巴比妥酸与芳氧基/芳胺基乙酰肼及含氮杂环乙酰肼缩合制备新型酰腙化合物,并对其抑菌活性进行评价的研究。新化合物的结构经过元素分析、红外光谱、核磁共振谱、质谱和X射线单晶衍射等技术手段确认。体外的抑菌活性实验显示,部分目标化合物呈现出优于环丙沙星的抑菌活性。经过构效关系分析表明,当芳基为含氮杂环时,所形成的化合物抗菌活性与芳基为苯环时相比明显较强,抑菌活性最强的酰腙化合物2t对金黄色葡萄球菌的最小抑菌浓度(MIC)值为0.8 g/L,对大肠杆菌的最小抑菌浓度(MIC)值为1.6 g/L。

English

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  • 收稿日期:  2015-11-03
  • 网络出版日期:  2016-03-24
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