二硫化钼量子点荧光传感器检测盐酸多西环素的研究

引用本文: 姜相宇, 付华, 张敏, 付志博, 王月荣, 章弘扬, 胡坪. 二硫化钼量子点荧光传感器检测盐酸多西环素的研究[J]. 分析化学, 2018, 46(7): 1077-1083. doi: 10.11895/j.issn.0253-3820.171347 shu

Citation: JIANG Xiang-Yu, FU Hua, Zhang Min, FU Zhi-Bo, WANG Yue-Rong, ZHANG Hong-Yang, HU Ping. Molybdenum Disulfide Quantum Dots-based Fluorescence Sensor for Detection of Doxycycline Hyclate[J]. Chinese Journal of Analytical Chemistry, 2018, 46(7): 1077-1083. doi: 10.11895/j.issn.0253-3820.171347 shu

二硫化钼量子点荧光传感器检测盐酸多西环素的研究

姜相宇 ^1, ,
付华 ^1, ,
张敏 ^2, ,
付志博 ^1, ,
王月荣 ^1, ,
章弘扬 ^1, ,
胡坪 ^1,

1.
上海市功能性材料化学重点实验室, 华东理工大学化学与分子工程学院, 上海 200237;
2.
上海市新药设计重点实验室, 华东理工大学药学院, 上海 200237
基金项目:
本文系国家自然科学基金项目（No.81573397）和上海市自然科学基金项目（No.15ZR1409400）资助

摘要: 通过水热法一步合成了二硫化钼（MoS₂）量子点。MoS₂量子点具有良好的荧光性能，基于盐酸多西环素（DOX）对MoS₂量子点荧光猝灭的特性，建立了基于MoS₂量子点荧光传感器测定DOX含量的方法。研究结果表明，DOX对MoS₂量子点荧光的猝灭机理为静态猝灭。此荧光传感器测定DOX的线性范围为0.86~55.40 μg/mL，检出限为0.023 μg/mL（S/N=3）。利用此方法对盐酸多西环素片剂和加标牛奶中的DOX含量进行测定，RSD<5%（n=3），测定结果与高效液相色谱法（HPLC）相比，相对误差<±5%（n=3）。本方法快速、简便，可用于实际样品中盐酸多西环素的测定。

关键词:

English

Molybdenum Disulfide Quantum Dots-based Fluorescence Sensor for Detection of Doxycycline Hyclate

1.
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East-China University of Science and Technology, Shanghai 200237, China;
2.
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Received Date: 17 October 2017
Revised Date: 08 April 2018
Fund Project:
This work was supported by the National Natural Science Foundation of China (No.81573397) and the Shanghai Natural Science Foundation (No.15ZR1409400).

Abstract: Molybdenum disulfide (MoS₂) quantum dots (QDs) were synthesized using one-step hydrothermal method with an acceptable fluorescence property. Based on the quenching effect between doxycycline hyclate (DOX) and MoS₂ QDs, a fluorescence method for detection of DOX was established. The interaction between MoS₂ QDs and DOX was discussed with a final proposal of the static quenching mechanism. A good linear correlation for detection of DOX using fluorescenct MoS₂ QDs was obtained in the concentration range of 0.86-55.40 μg/mL, with a detection limit of 0.023 μg/mL (S/N=3). The fabricated sensor was applied to the detection of DOX in real samples with RSDs of less than 5%. The relative error of determination results of MoS₂ QDs method compared with HPLC was from -4.5% to 0.8% and -4.6% to 2.8% for DOX tablet and DOX spiked milk, respectively. The fluorescence detection of DOX in real sample using MoS₂ QDs was simple, rapid and reliable.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

二硫化钼量子点荧光传感器检测盐酸多西环素的研究

English

Molybdenum Disulfide Quantum Dots-based Fluorescence Sensor for Detection of Doxycycline Hyclate

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

二硫化钼量子点荧光传感器检测盐酸多西环素的研究

English

Molybdenum Disulfide Quantum Dots-based Fluorescence Sensor for Detection of Doxycycline Hyclate

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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