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基于多肽与金属离子作用的一种高选择性Cd2+荧光比率传感器

王召璐 ,  冯慧云 ,  李艳 ,  许涛 ,  薛泽春 ,  李连之

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引用本文: 王召璐, 冯慧云, 李艳, 许涛, 薛泽春, 李连之. 基于多肽与金属离子作用的一种高选择性Cd2+荧光比率传感器[J]. 无机化学学报, 2015, 31(10): 1946-1952. doi: 10.11862/CJIC.2015.261 shu
Citation:  WANG Zhao-Lu, FENG Hui-Yun, LI Yan, XU Tao, XUE Ze-Chun, LI Lian-Zhi. A High Selective Fluorescent Ratio Sensor for Cd2+ Based on the Interaction of Peptide with Metal Ion[J]. Chinese Journal of Inorganic Chemistry, 2015, 31(10): 1946-1952. doi: 10.11862/CJIC.2015.261 shu

基于多肽与金属离子作用的一种高选择性Cd2+荧光比率传感器

  • 1.

    聊城大学化学化工学院, 聊城 252059

    • 通讯作者: 李连之,E-mail:lilianzhi1963@163.com
  • 基金项目:

    山东省自然科学基金(No.ZR2011BL002)资助项目。 (No.ZR2011BL002)

摘要: 利用固相多肽合成法合成了一种新的多肽,将该多肽与荧光基团Dansyl偶联制备了一种新的荧光化学比率传感器:Dansyl-Cys-Pro-Pro-Cys-Trp-NH2。利用荧光光谱研究了它与金属离子的相互作用。结果表明,与其它13种金属离子相比该多肽对金属Cd2+有很好的选择性。它能特异性识别Cd2+,具有水溶性好,响应时间快等优点。该肽对Cd2+具有很强的键合作用,其结合常数为3.0×1011 L2·mol-2,检出限为11.5 nmol·L-1。

English

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  • 收稿日期:  2015-01-11
  • 网络出版日期:  2015-07-23
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