注册 English

靶向抑制拓扑异构酶和端粒酶的钌配合物研究进展

陈相 ,  巢晖 ,  计亮年

downloadPDF
引用本文: 陈相, 巢晖, 计亮年. 靶向抑制拓扑异构酶和端粒酶的钌配合物研究进展[J]. 无机化学学报, 2015, 31(9): 1667-1677. doi: 10.11862/CJIC.2015.241 shu
Citation:  CHEN Xiang, CHAO Hui, JI Liang-Nian. New Trends of Ruthenium Complexes as Inhibitors Targeting Topoisomerase and Telomerase[J]. Chinese Journal of Inorganic Chemistry, 2015, 31(9): 1667-1677. doi: 10.11862/CJIC.2015.241 shu

靶向抑制拓扑异构酶和端粒酶的钌配合物研究进展

  • 1.

    中山大学化学与化学工程学院生物无机与合成化学教育部重点实验室, 广州 510275

    • 通讯作者: 巢晖,E-mail:ceschh@mail.sysu.edu.cn;计亮年,E-mail:cesjln@mail.sysu.edu.cn; 巢晖,E-mail:ceschh@mail.sysu.edu.cn;计亮年,E-mail:cesjln@mail.sysu.edu.cn
  • 基金项目:

    973项目(No.2015CB85630) (No.2015CB85630)

    国家自然科学基金(No.21172273,21171177,21471164) (No.21172273,21171177,21471164)

    教育部高校博士点基金博导类课题(No.20110171110013)资助项目。 (No.20110171110013)

摘要: 金属配合物抗肿瘤研究,尤其是铂类药物,已取得了相对令人瞩目的成功,但同时也面临着包括耐药性和毒副作用等诸多问题。近年来钌配合物作为新的抗癌药物引起了人们的注意。在非铂系药物中,金属钌配合物是最有前途的抗癌药物之一,国际上普遍认为钌和钌的配合物属于低毒性,容易吸收并在体内很快排泄。本文将着重介绍钌配合物与DNA结合后进一步引发的细胞内核酶活性抑制研究,从新的角度来诠释钌配合物的抗肿瘤研究最新进展。

English

  • 

    1. [1] Jamieson E J, Lippard S J. Chem. Rev., 1999,99:2467-2498[1] Jamieson E J, Lippard S J. Chem. Rev., 1999,99:2467-2498

    2. [2] Van Zutphen S, Reedijk J. Coord. Chem. Rev., 2005,249:2845-2853[2] Van Zutphen S, Reedijk J. Coord. Chem. Rev., 2005,249:2845-2853

    3. [3] Fuertes M A, A lonso C, Pérez J M. Chem. Rev., 2003,103:645-662[3] Fuertes M A, A lonso C, Pérez J M. Chem. Rev., 2003,103:645-662

    4. [4] Kelland L. Nat. Rev. Cancer, 2007,7:573-584[4] Kelland L. Nat. Rev. Cancer, 2007,7:573-584

    5. [5] Kostova I. Curr. Med. Chem., 2006,13:1085-1107[5] Kostova I. Curr. Med. Chem., 2006,13:1085-1107

    6. [6] Clark M J. Coord. Chem. Rev., 2002,232:69-93[6] Clark M J. Coord. Chem. Rev., 2002,232:69-93

    7. [7] Bergamo A, Sava G. Dalton Trans., 2007:1267-1272[7] Bergamo A, Sava G. Dalton Trans., 2007:1267-1272

    8. [8] CHEN Yu(陈禹), DU Ke-Jie(杜可杰), CHAO Hui(巢晖), et al. Prog. Chem.(化学进展), 2009,5:836-844[8] CHEN Yu(陈禹), DU Ke-Jie(杜可杰), CHAO Hui(巢晖), et al. Prog. Chem.(化学进展), 2009,5:836-844

    9. [9] Wang J C. Annu. Rev. Biochem., 1996,65:635-692[9] Wang J C. Annu. Rev. Biochem., 1996,65:635-692

    10. [10] QIAN Chen(钱晨), PENG Zai-Li(彭再利), CHAO Hui (巢晖). Univ. Chem.(大学化学), 2014,29:1-10[10] QIAN Chen(钱晨), PENG Zai-Li(彭再利), CHAO Hui (巢晖). Univ. Chem.(大学化学), 2014,29:1-10

    11. [11] Li T K, Liu L F. Annu. Rev. Pharmacol. Toxicol., 2001,41:53-77[11] Li T K, Liu L F. Annu. Rev. Pharmacol. Toxicol., 2001,41:53-77

    12. [12] Malonne H, Atassi G. Anti. Cancer Drugs, 1997,8:811-822[12] Malonne H, Atassi G. Anti. Cancer Drugs, 1997,8:811-822

    13. [13] John L N. Nat. Rev. Cancer, 2009,9:338-350[13] John L N. Nat. Rev. Cancer, 2009,9:338-350

    14. [14] MO Xiao-Mei(莫晓媚), LI Jing(李静), GENG Mei-Yu (耿美玉). Chinese Pharmaco. Bull. (中国药理学通报), 2007,1:20-23[14] MO Xiao-Mei(莫晓媚), LI Jing(李静), GENG Mei-Yu (耿美玉). Chinese Pharmaco. Bull. (中国药理学通报), 2007,1:20-23

    15. [15] Gopal Y N V, Jayaraju D, Kondapi A K. Biochemistry, 1999, 38:4382-4388[15] Gopal Y N V, Jayaraju D, Kondapi A K. Biochemistry, 1999, 38:4382-4388

    16. [16] Gao F, Chao H, Wang J Q, et al. J. Biol. Inorg. Chem., 2007, 12:1015-1027[16] Gao F, Chao H, Wang J Q, et al. J. Biol. Inorg. Chem., 2007, 12:1015-1027

    17. [17] Gao F, Chao H, Zhou F, et al. J. Inorg. Biochem., 2008,102:1050-1059[17] Gao F, Chao H, Zhou F, et al. J. Inorg. Biochem., 2008,102:1050-1059

    18. [18] Eder J P, Chan V, Wong J, et al. Cancer Chemother. Pharmacol., 1998,42:327-335[18] Eder J P, Chan V, Wong J, et al. Cancer Chemother. Pharmacol., 1998,42:327-335

    19. [19] Crump M, Lipton J, Hedley D, et al. Leukemia, 1999,13:343-347[19] Crump M, Lipton J, Hedley D, et al. Leukemia, 1999,13:343-347

    20. [20] Vey N, Kantarjian H, Beran M, et al. Invest. New Drugs, 1999,17:89-95[20] Vey N, Kantarjian H, Beran M, et al. Invest. New Drugs, 1999,17:89-95

    21. [21] Azarova A M, Lyu Y L, Lin C P, et al. Proc. Natl. Acad. Sci. USA, 2007,107:11014-11019[21] Azarova A M, Lyu Y L, Lin C P, et al. Proc. Natl. Acad. Sci. USA, 2007,107:11014-11019

    22. [22] Du K J, Wang J Q, Kou J F, et al. Eur. J. Med. Chem., 2011,46:1056-1065[22] Du K J, Wang J Q, Kou J F, et al. Eur. J. Med. Chem., 2011,46:1056-1065

    23. [23] Kou J F, Qian C, Wang J Q, et al. J. Biol. Inorg. Chem., 2012,17:81-96[23] Kou J F, Qian C, Wang J Q, et al. J. Biol. Inorg. Chem., 2012,17:81-96

    24. [24] Wang Y C, Qian C, Peng Z L, et al. J. Inorg. Chem., 2014, 130:15-27[24] Wang Y C, Qian C, Peng Z L, et al. J. Inorg. Chem., 2014, 130:15-27

    25. [25] Du K J, Liang J W, Wang Y, et al. Dalton Trans., 2014,43:17303-17316[25] Du K J, Liang J W, Wang Y, et al. Dalton Trans., 2014,43:17303-17316

    26. [26] Zhang P Y, Wang J Q, Huang H Y, et al. Dalton Trans., 2013,42:8907-8917[26] Zhang P Y, Wang J Q, Huang H Y, et al. Dalton Trans., 2013,42:8907-8917

    27. [27] He X J, Jin L H, Tan L F. Spectrochim. Acta A, 2015,135:101-109[27] He X J, Jin L H, Tan L F. Spectrochim. Acta A, 2015,135:101-109

    28. [28] He X J, Zeng L L, Yang G, et al. Inorg. Chim. Acta, 2013, 408:9-17[28] He X J, Zeng L L, Yang G, et al. Inorg. Chim. Acta, 2013, 408:9-17

    29. [29] Liu X W, Zhang S B, Li L, et al. Organomet. Chem., 2013, 729:1-8[29] Liu X W, Zhang S B, Li L, et al. Organomet. Chem., 2013, 729:1-8

    30. [30] Liu Y J, Zeng C H, Yao J H, et al. Chem. Biodivers., 2010, 7:1770-1783[30] Liu Y J, Zeng C H, Yao J H, et al. Chem. Biodivers., 2010, 7:1770-1783

    31. [31] Liu Y J, Zeng C H, Huang H L, et al. Eur. J. Med. Chem., 2011,45:564-571[31] Liu Y J, Zeng C H, Huang H L, et al. Eur. J. Med. Chem., 2011,45:564-571

    32. [32] Blackburn E H. J. Biol. Chem., 1990,265:5919-5921[32] Blackburn E H. J. Biol. Chem., 1990,265:5919-5921

    33. [33] Blackburn E H. Annu. Rev. Biochem., 1984,53:163-194[33] Blackburn E H. Annu. Rev. Biochem., 1984,53:163-194

    34. [34] Blackburn E H. Nature, 2000,408,53-56[34] Blackburn E H. Nature, 2000,408,53-56

    35. [35] Liu D, OConnor M S, Qin J, et al. J. Biol. Chem., 2004, 279,51338-51342[35] Liu D, OConnor M S, Qin J, et al. J. Biol. Chem., 2004, 279,51338-51342

    36. [36] Hiyama K, Hiyama E, Ishioka S, et al. J. Natl. Cancer Inst., 1995,87:895-902[36] Hiyama K, Hiyama E, Ishioka S, et al. J. Natl. Cancer Inst., 1995,87:895-902

    37. [37] Counter C M, Hirte H W, Bacchetti S, et al. Proc. Natl. Acad. Sci. USA, 1994,91:2900-2904[37] Counter C M, Hirte H W, Bacchetti S, et al. Proc. Natl. Acad. Sci. USA, 1994,91:2900-2904

    38. [38] Hiyama E, Yokoyama T, Tatsumoto N, et al. Cancer Res., 1995,55:3258-3262[38] Hiyama E, Yokoyama T, Tatsumoto N, et al. Cancer Res., 1995,55:3258-3262

    39. [39] Hiyama E, Gollahon L, Kataoka T, et al. J. Natl. Cancer Inst., 1996,88:116-122[39] Hiyama E, Gollahon L, Kataoka T, et al. J. Natl. Cancer Inst., 1996,88:116-122

    40. [40] Burge S, Parkinson G N, Hazel P, et al. Nucleic Acids Res., 2006,34:5402-5415[40] Burge S, Parkinson G N, Hazel P, et al. Nucleic Acids Res., 2006,34:5402-5415

    41. [41] Monchaud D, Teulade-Fichou M P. Org. Biomol. Chem., 2008, 6:627-636[41] Monchaud D, Teulade-Fichou M P. Org. Biomol. Chem., 2008, 6:627-636

    42. [42] Shay J W, Wright W E. Nat. Rev. Drug Discov., 2006,5:577-584[42] Shay J W, Wright W E. Nat. Rev. Drug Discov., 2006,5:577-584

    43. [43] Shi S, Liu J, Yao T M, et al. Inorg. Chem., 2008,47:2910-2912[43] Shi S, Liu J, Yao T M, et al. Inorg. Chem., 2008,47:2910-2912

    44. [44] Xu L, Liao G L, Chen X, et al. Inorg. Chem. Commun., 2010,13:1050-10053[44] Xu L, Liao G L, Chen X, et al. Inorg. Chem. Commun., 2010,13:1050-10053

    45. [45] Chen X, Wu J H, Lai Y W, et al. Dalton Trans., 2013,42:4386-4397[45] Chen X, Wu J H, Lai Y W, et al. Dalton Trans., 2013,42:4386-4397

    46. [46] Liao G L, Chen X, Wu J H, et al. Dalton Trans., 2014,43:7811-7819[46] Liao G L, Chen X, Wu J H, et al. Dalton Trans., 2014,43:7811-7819

    47. [47] Xu L, Chen X, Wu J H, et al. Chem. Eur. J., 2015,21:4008-4020[47] Xu L, Chen X, Wu J H, et al. Chem. Eur. J., 2015,21:4008-4020

    48. [48] Yu Q Q, Liu Y N, Xu L, et al. Eur. J. Med. Chem., 2014, 82:82-95[48] Yu Q Q, Liu Y N, Xu L, et al. Eur. J. Med. Chem., 2014, 82:82-95

    49. [49] Zhang J N, Yu Q Q, Li Q, et al. J. Inorg. Biochem., 2014,134:1-11[49] Zhang J N, Yu Q Q, Li Q, et al. J. Inorg. Biochem., 2014,134:1-11

    50. [50] Li Q, Zhang J N, Yang L C, et al. J. Inorg. Biochem., 2014, 130:122-129[50] Li Q, Zhang J N, Yang L C, et al. J. Inorg. Biochem., 2014, 130:122-129

    51. [51] Xia Y, Chen Q C, Qin X Y, et al. New J. Chem., 2013,37:3706-3715[51] Xia Y, Chen Q C, Qin X Y, et al. New J. Chem., 2013,37:3706-3715

    52. [52] Li Q, Sun D D, Zhou Y H, et al. Inorg. Chem. Commun., 2012,20:142-146[52] Li Q, Sun D D, Zhou Y H, et al. Inorg. Chem. Commun., 2012,20:142-146

    53. [53] Yu Q Q, Liu Y Y, Zhang J N, et al. Metallomics, 2013,5:222-231[53] Yu Q Q, Liu Y Y, Zhang J N, et al. Metallomics, 2013,5:222-231

    54. [54] Sun D D, Zhang R, Yuan F, et al. Dalton Trans., 2012,41:1734-1741[54] Sun D D, Zhang R, Yuan F, et al. Dalton Trans., 2012,41:1734-1741

    55. [55] Yu Q Q, Liu Y N, Wang C, et al. PloS one, 2012,7:e50902[55] Yu Q Q, Liu Y N, Wang C, et al. PloS one, 2012,7:e50902

    56. [56] Sun D D, Liu Y N, Liu D, et al. Chem. Eur. J., 2012,18:4285-4295[56] Sun D D, Liu Y N, Liu D, et al. Chem. Eur. J., 2012,18:4285-4295

    57. [57] Shi S, Gao S N, Cao T C, et al. PloS one, 2013,8:e84419[57] Shi S, Gao S N, Cao T C, et al. PloS one, 2013,8:e84419

    58. [58] Kim M Y, Duan W, Guzman M G, et al. J. Med. Chem., 2003, 46:571-583[58] Kim M Y, Duan W, Guzman M G, et al. J. Med. Chem., 2003, 46:571-583

    59. [59] Von S T, Seng H L, Lee H B, et al. J. Biol. Inorg. Chem., 2012,17:57-69[59] Von S T, Seng H L, Lee H B, et al. J. Biol. Inorg. Chem., 2012,17:57-69

    60. [60] Liao G L, Chen X, Wu J H, et al. Dalton Trans., 2015,DOI: 10.1039/c4dt03585b[60] Liao G L, Chen X, Wu J H, et al. Dalton Trans., 2015,DOI: 10.1039/c4dt03585b

  • 加载中
WeChat 扫一扫看文章
计量
  • PDF下载量:  0
  • 文章访问数:  464
  • HTML全文浏览量:  41
文章相关
  • 收稿日期:  2015-05-20
  • 网络出版日期:  2015-07-15
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

/

返回文章

All Rights Reserved by the Chinese Chemical Society   中国化学会 版权所有 京ICP备05002797号

本系统由北京仁和汇智信息技术有限公司开发    技术支持: info@rhhz.net