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二[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)n[CO2Sn(CH2CMe2Ph)3]2(n=2,3,4)的合成、结构及体外抗癌活性

邝代治 ,  朱小明 ,  冯泳兰 ,  张复兴 ,  庾江喜 ,  蒋伍玖 ,  谭宇星 ,  张志坚

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引用本文: 邝代治, 朱小明, 冯泳兰, 张复兴, 庾江喜, 蒋伍玖, 谭宇星, 张志坚. 二[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)n[CO2Sn(CH2CMe2Ph)3]2(n=2,3,4)的合成、结构及体外抗癌活性[J]. 无机化学学报, 2015, 31(10): 2001-2007. doi: 10.11862/CJIC.2015.211 shu
Citation:  KUANG Dai-Zhi, ZHU Xiao-Ming, FENG Yong-Lan, ZHANG Fu-Xing, YU Jiang-Xi, JIANG Wu-Jiu, TAN Yu-Xing, ZHANG Zhi-Jian. Syntheses, Crystal Structures and in vitro Anti-tumor Activity of Three Bis[tris(2-methyl-2-phenyl)propyltin]dicarboxylate (CH2)n[CO2Sn(CH2CMe2Ph)3]2 (n=2, 3, 4)[J]. Chinese Journal of Inorganic Chemistry, 2015, 31(10): 2001-2007. doi: 10.11862/CJIC.2015.211 shu

二[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)n[CO2Sn(CH2CMe2Ph)3]2(n=2,3,4)的合成、结构及体外抗癌活性

  • 1.

    1 衡阳师范学院化学与材料科学学院;功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008;

  • 2.

    2 衡阳师范学院生命科学与环境学院, 衡阳 421008

    • 通讯作者: 邝代治,E-mail:hnkcq@qq.com
  • 基金项目:

    湖南省自然科学基金(No.13JJ3112) (No.13JJ3112)

    科技计划(No.2013TZ2025,2014NK3086,2014FJ3060) (No.2013TZ2025,2014NK3086,2014FJ3060)

    功能金属有机材料湖南省普通高校重点实验室开放基金资助项目(No.13K105,14K014,13K01-05,GN14K01) (No.13K105,14K014,13K01-05,GN14K01)

    衡阳师范学院科学基金(No.12C45) (No.12C45)

    湖南省重点学科基金和湖南省高校科技创新团队支持计划,湖南省教育厅基金(No.15C0200,15C0200)资助项目。 (No.15C0200,15C0200)

摘要: 丁二酸、戊二酸和己二酸分别与μ-氧-双[三(2-甲基-2-苯基)丙基]锡反应,合成了3个二[三(2-甲基-2-苯基)丙基锡]二元酸酯(CH2)n[CO2Sn(CH2CMe2Ph)3]2(n=2(1),3(2),4(3))。对化合物1~3进行了元素分析、红外光谱及核磁共振(1H,13C)表征,并通过X-射线晶体衍射分析测定晶体结构。化合物中锡与配基原子构成畸型四面体构型。试验表明,化合物2和3均对人癌细胞Colo205、HepG2、MCF-7、Hela、NCI-H460的增殖具有较强的抑制作用。

English

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  • 收稿日期:  2015-03-09
  • 网络出版日期:  2015-05-31
通讯作者: 陈斌, bchen63@163.com
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