Chloride anion-induced dimer capsule based on a polyfluorinated macrocycle meta-WreathArene

Shu Niu Hongyan Xiao Xiao-Di Yang Huan Cong

Citation:  Shu Niu, Hongyan Xiao, Xiao-Di Yang, Huan Cong. Chloride anion-induced dimer capsule based on a polyfluorinated macrocycle meta-WreathArene[J]. Chinese Chemical Letters, 2023, 34(7): 108042. doi: 10.1016/j.cclet.2022.108042 shu

Chloride anion-induced dimer capsule based on a polyfluorinated macrocycle meta-WreathArene

English

  • The construction of artificial capsules is a rapidly advancing direction in the field of supramolecular self-assembly [1-5]. Among the widely-used building blocks for artificial capsules, macrocycles, especially [1n]metacyclophanes ([1n]MCPs) with cone-shaped conformations, have attracted much attention [6-8]. [1n]MCPs feature neutral macrocyclic backbones composed of methylene-bridged meta-phenylenes, where n represents the number of arene moieties in the molecular skeleton [9,10]. In the [1n]MCP family, [14]MCPs containing electron-rich arenes, such as calix[4]arene, resorcin[4]arene and pyrogallol[4]arene, are the most studied ones because of their facile synthesis (Fig. 1a) [11-13]. The upper rims of [14]MCPs are often functionalized for artificial capsule formation through various assembly mechanisms including hydrogen bonds [14-17], electrostatic interactions [18-21], and metal-ligand coordinations [22-29]. In parallel to these capsule-assembly approaches, although anions have been frequently present in the process of [1n]MCP-based capsule formation [30-34], literature examples on anion-induced molecular capsules through the assembly of [1n]MCPs remain limited [35-38].

    Figure 1

    Figure 1.  (a) [14]MCP macrocycles containing electron-rich arenes. (b) Polyfluorinated cyclophanes. (c) Chloride anion-induced capsule formation of meta-WreathArene (mWA).

    In addition, Friedel–Crafts-type reactions are predominant methods for the preparations of conventional [14]MCPs which require electron-rich arene subunits on the macrocyclic skeletons [11-17]. We envisioned that the development of efficient synthesis of complementary [14]MCPs bearing electron-withdrawing groups would facilitate the discovery of new supramolecular properties. Instead of late-stage functionalizations on the macrocycle rims [39,40], we have recently developed a convergent access to WreathArene, a polyfluorinated [16]paracyclophane (Fig. 1b) [41], employing direct C–H activation/coupling reactions to construct its electron-deficient arene scaffold. As our continuing quest to utilize this synthetic approach, here we present the preparation and properties of a novel polyfluorinated [14]MCP, meta-WreathArene (mWA). Prepared through three steps from tetrafluorobenzene, mWA can bind chloride anions both in solution and in solid state, and form hydrogen-bonded molecular capsules, each of which contains two macrocycles and two chlorides (Fig. 1c).

    The synthesis of mWA commenced with Pd-catalyzed C-H activation/coupling [42] between bis(benzyl bromide) 1 and excess 1, 2, 3, 5-tetrafluorobenzene. The resulting polyfluorinated 2 further coupled with 1 to furnish two C(sp2)–C(sp3) bonds, and afforded the cyclized product 3. Treatment of 3 with BBr3 smoothly removed the methyl groups to provide mWA (Fig. 2a), which were characterized by 1H, 13C and 19F NMR and high-resolution mass spectrometry (Figs. S7–S10 in Supporting information). In parallel to the hydroxyl‑containing mWA, its tert‑butyl and unsubstituted analogues were also obtained successfully following the same synthetic strategy, showing the utility of this method for versatile polyfluorinated [14]metacyclophanes (Fig. S11 in Supporting information).

    Figure 2

    Figure 2.  (a) The synthesis of mWA. (b) 19F–1H HOESY spectra of mWA (4 mmol/L) in acetone-d6 (600 MHz, 298 K).

    In analogy to calix[4]arene [43,44], mWA may have multiple conformations caused by possible rotations of the arene moieties. Accordingly, conformational analyses of mWA in solution was conducted using the 19F–1H heteronuclear overhauser enhancement spectroscopy (HOESY) which reflects important intramolecular spatial information between the hydrogen and fluorine atoms (Fig. 2b) [45,46]. The HOESY spectra of mWA in acetone-d6 showed evident spatial correlations between the following heteronuclear pairs: F2–Ha, F2–Hc/Hd (overlapped), F3–Hb and F3–Hc/Hd (overlapped); whereas correlations for other possible combinations, particularly F2–Hb and F3–Ha, were absent. These observations suggest that mWA should prefer to adopt the cone conformation in acetone solution (Fig. S21 in Supporting information).

    Next, the anion binding properties of mWA were explored through NMR titration experiments. Upon mixing mWA with increasing amount of n-Bu4NCl in acetone-d6, the proton NMR signals of mWA evidently shifted, suggesting the existence of non-covalent interactions. Further examination revealed that the most significant changes were the downfield-shifted HOH signals. The Ha and Hb signals, which correspond to the ortho- and para-protons to the hydroxyl group of the same meta-phenylene moiety, moderately shifted toward downfield and upfield, respectively (Fig. 3a). In contrast, minimal changes were observed for the Hc and Hd of mWA and the butyl protons of the tetraalkylammonium cation. These results indicate that the non-covalent interactions of mWA and n-Bu4NCl most likely occur between the hydroxyl groups and chloride anions. Indeed, when the mWA's hydroxyl groups are protected or replaced, the corresponding mWA analogues display negligible changes of their proton NMR spectra in the presence of n-Bu4NCl (Fig. S29 in Supporting information). In addition, larger halides (Br and I) exhibit significantly weakened interactions with mWA, and non-halide anions including SCN, NO3, ClO4, BF4 and PF6 were found inactive under otherwise identical conditions (Figs. S31 and S32 in Supporting information). The interactions between chloride anions and mWA remain evident by NMR when the tetrabutylammonium cation was replaced by Et4N+ and BnEt3N+ (Fig. S33 in Supporting information). The results of these control experiments again support the correlations between the supramolecular changes of mWA and the effect of chloride anion.

    Figure 3

    Figure 3.  (a) NMR titration of mWA (1 mmol/L) by n-Bu4NCl in acetone-d6 (400 MHz, 298 K). (b) Mole ratio plot indicating a stoichiometric ratio of 1 for mWA and n-Bu4NCl. (c) High-resolution mass spectrometry of an acetone solution of equimolar mWA and n-Bu4NCl. (d) DOSY spectrum of mWA (10 mmol/L) in acetone-d6 (600 MHz, 298 K). (e) DOSY spectrum of mWA (10 mmol/L) in the presence of equimolar n-Bu4NCl in acetone-d6 (600 MHz, 298 K).

    Having identified the chloride binding property of mWA, we recorded the molar ratio plot and Job's plots, both of which showed a stoichiometric ratio of 1 for the supramolecular complex consisting of mWA and chloride (Fig. 3b and Fig. S27 in Supporting information). Based on the observation of [mWA]2[Cl]2[n-Bu4N+] anionic species by high-resolution mass spectrometry analysis of an equimolar solution of mWA and n-Bu4NCl, the exact stoichiometry was suggested as 2:2 (Fig. 3c and Fig. S28 in Supporting information).

    Furthermore, diffusion-ordered NMR spectroscopy (DOSY) analysis was employed to investigate the supramolecular complex formation in solution (Figs. 3d and e) [47]. The DOSY spectrum of mWA in acetone-d6 at 298 K displayed a single band of signals with a diffusion coefficient (D) of 1.77 × 10−9 m2/s. According to the spherical model of Stocks–Einstein equation, the hydrodynamic diameter of mWA was calculated as 0.81 nm (Table S1 in Supporting information), matching the size of a single macrocycle observed in the crystal structure (Fig. 4a). In comparison, DOSY signals of mWA in the presence of equimolar n-Bu4NCl exhibited two distinct sets of bands corresponding to the protons of mWA and n-Bu4N+, respectively. In addition, the n-Bu4N+ signals also changed upon mixing with mWA, suggesting that the tetraalkylammonium cations are not fully encapsulated in, but may form tight ion pairs with the supramolecular complexes in solution [35-38].

    Figure 4

    Figure 4.  (a) Crystal structure of chloride-induced dimer capsule of mWA. (b, c) Solid-state molecular packing viewed along c-axis and (111)-plane, respectively. Solvents and cations were omitted for clarity.

    In particular, the diffusion coefficient of mWA in the presence of equimolar n-Bu4NCl decreased to 1.32 × 10−9 m2/s, which is convertible to an estimated hydrodynamic diameter of 1.1 nm (Fig. 4a). The enhanced diameter value suggests the chloride-induced formation of supramolecular aggregates, consistent with the aforementioned 2:2 stoichiometry for mWA and chloride anion.

    Further evidence for the 2:2 mWA–chloride supramolecular aggregate was obtained through solid-state crystal structure. After extensive attempts, suitable single crystals containing tetragonal unit cells were grown by slow diffusion of diethyl ether into a solution of mWA and excess Et4NCl in mixed solvents of acetone and acetonitrile (Fig. 4). Consistent with the solution-based characterizations (NMR titration, mass spectrometry, and DOSY), the crystal structure unambiguiously displays a molecular capsule of two cone-shaped mWA connected by two chloride anions (Fig. 4a). The upper-rims of the two mWA macrocycles face each other, and each chloride interacts with two hydroxyl groups through hydrogen-bonds with an average O–H···Cl distance of 2.1 Å [48-52]. Matching the calculated diameter value based on DOSY data of Fig. 3e, the dimensions of the capsule in the solid state are measured as 11.5 Å in width (distance between the chlorides), 10.4 Å in depth (distance between the fluorine atoms at the upper-rim of the same macrocycle), and 12.2 Å in height (distance between the top and bottom fluorine atoms). Inspection of the molecular packing revealed that the capsules adopt two orthogonal orientations in the crystal structure. Through inter-capsule π···π interactions [53,54], each fluorinated arene is always facing an unfluorinated arene of another macrocycle to stabilize dense packing (Figs. 4b and c). In addition, the disordered Et4N+cations are located at the capsule cavities as well as the vacancies surrounded by capsules in the crystal structure (Figs. S39 and S40 in Supporting information).

    To further assess the chloride anion-induced dimer capsule formation of mWA, the geometries of mWA and its dimer capsule were optimized by DFT calculations (Fig. 5). The calculated energies indicate that the strength of a single O–H···Cl hydrogen-bond is 27.3 kJ/mol [55], based on the formation of a 1:1 mWA–chloride intermediate. In addition, the capsule assembly from two 1:1 mWA–chloride intermediates ([mWA][Cl]) leads to an estimated 37.3 kJ/mol energy downhill. Thus, the overall capsule formation is thermodynamically favoured with −91.9 kJ/mol [equals to (−27.3) × 2 + (−37.3)] relative to two molecules of mWA and two chloride anions, which matches with the experimental observations in solution and in crystalline state.

    Figure 5

    Figure 5.  Theoretical calculation of chloride-induced dimer capsule formation of mWA.

    In conclusion, we have synthesized a polyfluorinated cyclophane mWA via direct C–H activation/coupling reactions. The notable feature of this C2-symmetrical macrocycle is the chloride anion-induced formation of a 2:2 dimer capsule which were characterized both in solution and in solid state. Further investigation on the development of anion-binding arene-based macrocycles is ongoing in our laboratory, and will be reported in due course.

    The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

    Financial support from the National Natural Science Foundation of China (Nos. 21922113, 22071257, 21988102), Chinese Academy of Sciences (No. XDB17000000), the National Key Research and Development Program (No. 2017YFA0206903), and the TIPC Director's Fund is gratefully acknowledged. We thank the NMR facility of National Center for Protein Sciences at Peking University. We thank Drs. Hongwei Li, Jie Su, and Wen Zhou (Peking University) for the help with sample characterizations, and Ms. Ziye Huo (TIPC-CAS) for assistance with compound preparation.

    Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.cclet.2022.108042.


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  • Figure 1  (a) [14]MCP macrocycles containing electron-rich arenes. (b) Polyfluorinated cyclophanes. (c) Chloride anion-induced capsule formation of meta-WreathArene (mWA).

    Figure 2  (a) The synthesis of mWA. (b) 19F–1H HOESY spectra of mWA (4 mmol/L) in acetone-d6 (600 MHz, 298 K).

    Figure 3  (a) NMR titration of mWA (1 mmol/L) by n-Bu4NCl in acetone-d6 (400 MHz, 298 K). (b) Mole ratio plot indicating a stoichiometric ratio of 1 for mWA and n-Bu4NCl. (c) High-resolution mass spectrometry of an acetone solution of equimolar mWA and n-Bu4NCl. (d) DOSY spectrum of mWA (10 mmol/L) in acetone-d6 (600 MHz, 298 K). (e) DOSY spectrum of mWA (10 mmol/L) in the presence of equimolar n-Bu4NCl in acetone-d6 (600 MHz, 298 K).

    Figure 4  (a) Crystal structure of chloride-induced dimer capsule of mWA. (b, c) Solid-state molecular packing viewed along c-axis and (111)-plane, respectively. Solvents and cations were omitted for clarity.

    Figure 5  Theoretical calculation of chloride-induced dimer capsule formation of mWA.

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  • 发布日期:  2023-07-15
  • 收稿日期:  2022-10-06
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