引用本文:
Hai Qian, Wei Chen, Jin Pei Zhou, Wen Long Huang, Hui Bin Zhang, Jing Jin. Total synthesis of endothelin 1 by microwave-assisted solid phase method[J]. Chinese Chemical Letters,
2010, 21(4): 388-390.
doi:
10.1016/j.cclet.2009.12.016
Citation: Hai Qian, Wei Chen, Jin Pei Zhou, Wen Long Huang, Hui Bin Zhang, Jing Jin. Total synthesis of endothelin 1 by microwave-assisted solid phase method[J]. Chinese Chemical Letters, 2010, 21(4): 388-390. doi: 10.1016/j.cclet.2009.12.016
Citation: Hai Qian, Wei Chen, Jin Pei Zhou, Wen Long Huang, Hui Bin Zhang, Jing Jin. Total synthesis of endothelin 1 by microwave-assisted solid phase method[J]. Chinese Chemical Letters, 2010, 21(4): 388-390. doi: 10.1016/j.cclet.2009.12.016
Total synthesis of endothelin 1 by microwave-assisted solid phase method
摘要:
A microwave-assisted solid phase synthesis for endothelin 1 is presented.Reduced endothelin 1 was synthesized efficiently on Wang resin under microwave irradiation using Fmoc/tBu orthogonal protection strategy.The whole peptide was cleaved from the resin and two disulphide bridges were formed under air oxidation at room temperature.The purity and efficiency of synthesizing the peptide is much higher than other methods used before.
English
Total synthesis of endothelin 1 by microwave-assisted solid phase method
Abstract:
A microwave-assisted solid phase synthesis for endothelin 1 is presented.Reduced endothelin 1 was synthesized efficiently on Wang resin under microwave irradiation using Fmoc/tBu orthogonal protection strategy.The whole peptide was cleaved from the resin and two disulphide bridges were formed under air oxidation at room temperature.The purity and efficiency of synthesizing the peptide is much higher than other methods used before.
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Key words:
- Endothelin 1
- / Microwave irradiation
- / Solid phase
- / Disulphide bridge
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