引用本文:
Li Qin He, Jing Liu, Deng Ke Yin, Yi Hua Zhang, Xiao Shan Wang. Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents[J]. Chinese Chemical Letters,
2010, 21(4): 381-384.
doi:
10.1016/j.cclet.2009.11.033
Citation: Li Qin He, Jing Liu, Deng Ke Yin, Yi Hua Zhang, Xiao Shan Wang. Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents[J]. Chinese Chemical Letters, 2010, 21(4): 381-384. doi: 10.1016/j.cclet.2009.11.033
Citation: Li Qin He, Jing Liu, Deng Ke Yin, Yi Hua Zhang, Xiao Shan Wang. Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents[J]. Chinese Chemical Letters, 2010, 21(4): 381-384. doi: 10.1016/j.cclet.2009.11.033
Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents
摘要:
A series of furoxan-based nitric oxide-releasing matrine derivatives(10a-f)were synthesized.The biological evaluation showed that compounds 10a,10b,10e and 10f had stronger cytotoxic activities than 5-fluorouracil against human hepatoma cells(HepG2) in vitro.
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关键词:
- Matrine
- / Furoxan
- / Anti-minor activity
- / HepG
English
Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents
Abstract:
A series of furoxan-based nitric oxide-releasing matrine derivatives(10a-f)were synthesized.The biological evaluation showed that compounds 10a,10b,10e and 10f had stronger cytotoxic activities than 5-fluorouracil against human hepatoma cells(HepG2) in vitro.
-
Key words:
- Matrine
- / Furoxan
- / Anti-minor activity
- / HepG
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