Investigation of the interaction between HⅣ-1 DNA and cyclic peptides by electrospray ionization mass spectrometry

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Investigation of the interaction between HⅣ-1 DNA and cyclic peptides by electrospray ionization mass spectrometry

Yi Quan Liu , Hui Hui Li , Yun Hua Ye , Gu Yuan

引用本文: Yi Quan Liu, Hui Hui Li, Yun Hua Ye, Gu Yuan. Investigation of the interaction between HⅣ-1 DNA and cyclic peptides by electrospray ionization mass spectrometry[J]. Chinese Chemical Letters, 2009, 20(3): 330-333. doi: 10.1016/j.cclet.2008.11.020 shu

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Citation: Yi Quan Liu, Hui Hui Li, Yun Hua Ye, Gu Yuan. Investigation of the interaction between HⅣ-1 DNA and cyclic peptides by electrospray ionization mass spectrometry[J]. Chinese Chemical Letters, 2009, 20(3): 330-333. doi: 10.1016/j.cclet.2008.11.020 shu

shu

Investigation of the interaction between HⅣ-1 DNA and cyclic peptides by electrospray ionization mass spectrometry

a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;
b School of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097, China
基金项目:
Project supported by the Research Fund for the Doctoral Program of Higher Education.

摘要: The interaction between HⅣ-1 DNA and five cyclic peptides (CP1-CP5) was investigated using electrospray ionization mass spectrometry (ESI-MS). It revealed that CP1 [c(Ala-Tyr-Leu-Ala-Gly)] and CP4 [c(Pro-D-Tyr-Leu-D-Ala-Gly)] have the higher binding affinity with the duplex DNA among the five cyclic peptides.

关键词:

HⅣ-1 DNA
/ Cyclic peptide
/ ESI-MS

English

Investigation of the interaction between HⅣ-1 DNA and cyclic peptides by electrospray ionization mass spectrometry

a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;
b School of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097, China
Received Date: 28 August 2008
Fund Project:
Project supported by the Research Fund for the Doctoral Program of Higher Education.

Abstract: The interaction between HⅣ-1 DNA and five cyclic peptides (CP1-CP5) was investigated using electrospray ionization mass spectrometry (ESI-MS). It revealed that CP1 [c(Ala-Tyr-Leu-Ala-Gly)] and CP4 [c(Pro-D-Tyr-Leu-D-Ala-Gly)] have the higher binding affinity with the duplex DNA among the five cyclic peptides.

Key words:

HⅣ-1 DNA
/ Cyclic peptide
/ ESI-MS

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