引用本文:
Qiu Hua Wu, Fang Liang, Tian Zhu Wei, Xi Ming Song, Shu Yao Wu, Guo Lin Zhang. Synthesis and characterization of a novel amphiphilic biodegradable β-cyclodextrin/poly(γ-benzyl L-glutamate) copolymer[J]. Chinese Chemical Letters,
2009, 20(3): 362-365.
doi:
10.1016/j.cclet.2008.11.016
Citation: Qiu Hua Wu, Fang Liang, Tian Zhu Wei, Xi Ming Song, Shu Yao Wu, Guo Lin Zhang. Synthesis and characterization of a novel amphiphilic biodegradable β-cyclodextrin/poly(γ-benzyl L-glutamate) copolymer[J]. Chinese Chemical Letters, 2009, 20(3): 362-365. doi: 10.1016/j.cclet.2008.11.016
Citation: Qiu Hua Wu, Fang Liang, Tian Zhu Wei, Xi Ming Song, Shu Yao Wu, Guo Lin Zhang. Synthesis and characterization of a novel amphiphilic biodegradable β-cyclodextrin/poly(γ-benzyl L-glutamate) copolymer[J]. Chinese Chemical Letters, 2009, 20(3): 362-365. doi: 10.1016/j.cclet.2008.11.016
Synthesis and characterization of a novel amphiphilic biodegradable β-cyclodextrin/poly(γ-benzyl L-glutamate) copolymer
摘要:
β-Cyclodextrin/poly(γ-benzyl L-glutamate) (β-CD-PBLG) copolymers were synthesized by ring-opening polymerization of N-carboxy-γ-benzyl L-glutamate anhydride (BLG-NCA) in N,N-dimethylformamide (DMF) initiated by mono-amino-β-cyclodextrin(H2N-β-CD). The structures of the copolymers were confirmed by IR, 1H NMR and GPC. The fluorescence technique was used to determine the critical micelle concentrations (CMC) of copolymer micell solution, the diameter and the distribution of micelles were characterized by DLS. The results showed that BLG-NCA could be initiated by H2N-β-CD to produce copolymer. The nanomicells were formed by these copolymers in water.
English
Synthesis and characterization of a novel amphiphilic biodegradable β-cyclodextrin/poly(γ-benzyl L-glutamate) copolymer
Abstract:
β-Cyclodextrin/poly(γ-benzyl L-glutamate) (β-CD-PBLG) copolymers were synthesized by ring-opening polymerization of N-carboxy-γ-benzyl L-glutamate anhydride (BLG-NCA) in N,N-dimethylformamide (DMF) initiated by mono-amino-β-cyclodextrin(H2N-β-CD). The structures of the copolymers were confirmed by IR, 1H NMR and GPC. The fluorescence technique was used to determine the critical micelle concentrations (CMC) of copolymer micell solution, the diameter and the distribution of micelles were characterized by DLS. The results showed that BLG-NCA could be initiated by H2N-β-CD to produce copolymer. The nanomicells were formed by these copolymers in water.
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