引用本文:
Ling Li Wu, Wei Zhao, Quan Min Li. Indirect determination of cefradine with n-propyl alcohol-ammonium sulfate-water system by extraction-flotation of cuprous thiocyanate[J]. Chinese Chemical Letters,
2008, 19(5): 565-568.
doi:
10.1016/j.cclet.2008.03.033
Citation: Ling Li Wu, Wei Zhao, Quan Min Li. Indirect determination of cefradine with n-propyl alcohol-ammonium sulfate-water system by extraction-flotation of cuprous thiocyanate[J]. Chinese Chemical Letters, 2008, 19(5): 565-568. doi: 10.1016/j.cclet.2008.03.033
Citation: Ling Li Wu, Wei Zhao, Quan Min Li. Indirect determination of cefradine with n-propyl alcohol-ammonium sulfate-water system by extraction-flotation of cuprous thiocyanate[J]. Chinese Chemical Letters, 2008, 19(5): 565-568. doi: 10.1016/j.cclet.2008.03.033
Indirect determination of cefradine with n-propyl alcohol-ammonium sulfate-water system by extraction-flotation of cuprous thiocyanate
摘要:
A new method was developed for the determination of cefradine by extraction-flotation of CuSCN. The experiment indicatedthat in the presence of 0.20 mol/L NaOH the degradation of cefradine took place in water bath at 100℃. The thiol group (-SH) ofthe degradation product could reduce Cu(Ⅱ) to Cu(Ⅰ) for the formation of the emulsion CuSCN in the presence of NH4SCN at pH4.0. By determining the residual amount of Cu(Ⅱ) in the solution and calculating the flotation yield of Cu(Ⅱ), the indirectdetermination of cefradine can be obtained. This method has been applied to determine cefradine in capsules, human serum andurine samples, respectively.
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关键词:
- Cefradine
- / Copper(Ⅱ)
- / n-Propyl alcohol
- / Extraction-flotation.
English
Indirect determination of cefradine with n-propyl alcohol-ammonium sulfate-water system by extraction-flotation of cuprous thiocyanate
Abstract:
A new method was developed for the determination of cefradine by extraction-flotation of CuSCN. The experiment indicatedthat in the presence of 0.20 mol/L NaOH the degradation of cefradine took place in water bath at 100℃. The thiol group (-SH) ofthe degradation product could reduce Cu(Ⅱ) to Cu(Ⅰ) for the formation of the emulsion CuSCN in the presence of NH4SCN at pH4.0. By determining the residual amount of Cu(Ⅱ) in the solution and calculating the flotation yield of Cu(Ⅱ), the indirectdetermination of cefradine can be obtained. This method has been applied to determine cefradine in capsules, human serum andurine samples, respectively.
-
Key words:
- Cefradine
- / Copper(Ⅱ)
- / n-Propyl alcohol
- / Extraction-flotation.
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