Synthesis, DNA binding and topoisomerase inhibition of mononaphthalimide homospermidine derivatives

• Zhi Yong Tian ^a,b, ,
• Hong Xia Ma ^b, ,
• Song Qiang Xie ^b, ,
• Xue Wang ^c, ,
• Jin Zhao ^b, ,
• Chao Jie Wang ^c, ,
• Wen Yuan Gao ^a,

• a School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China;

• b Institute of Natural Products & Medicinal Chemistry, Henan University, Kaifeng 475001, China;

• c Chemistry Department, Henan University, Kaifeng 475001, China

• Received Date: 22 November 2007
  
• Fund Project:

  and Henan Natural Science Foundations (Nos.0512001300

  072102330028).

  This work is supported by the National Natural Science Foundation of China (No.20472016)